Chemistry:AC-42
From HandWiki
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| Preferred IUPAC name
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine | |
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C20H31NO | |
| Molar mass | 301.474 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
AC-42 is a selective, allosteric agonist of the M1 muscarinic acetylcholine receptor. AC-42 was the first selective M1 agonist to be discovered and its derivatives have been used to study the binding domain of the M1 receptor.[1][2][3]
References
- ↑ Decker, Michael; Holzgrabe, Ulrike (2012). "M1 muscarinic cetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease". MedChemComm 3 (7): 752. doi:10.1039/c2md20025b.
- ↑ Sams, Anette G.; Hentzer, Morten; Mikkelsen, Gitte K.; Larsen, Krestian; Bundgaard, Christoffer; Plath, Niels; Christoffersen, Claus T.; Bang-Andersen, Benny (9 September 2010). "Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential". Journal of Medicinal Chemistry 53 (17): 6386–6397. doi:10.1021/jm100697g. PMID 20684563.
- ↑ Daval, Sandrine B.; Valant, Céline; Bonnet, Dominique; Kellenberger, Esther; Hibert, Marcel; Galzi, Jean-Luc; Ilien, Brigitte (8 March 2012). "Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors". Journal of Medicinal Chemistry 55 (5): 2125–2143. doi:10.1021/jm201348t. PMID 22329602. https://hal.archives-ouvertes.fr/hal-02193850/file/2012%20Daval%20%20J%20med%20Chem%20%281%29.pdf.
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