Chemistry:Milameline
From HandWiki
Short description: Chemical compound
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| Formula | C8H14N2O |
| Molar mass | 154.213 g·mol−1 |
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Milameline (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that was being investigated for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued.[1]
- Changing the O-methyl aldoxime to an O-propargyl oxime instead gives a separate molecule called RU 35986.[2]
See also
References
- ↑ "Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease". Life Sciences 56 (11–12): 877–882. 1995. doi:10.1016/0024-3205(95)00023-Y. PMID 10188788.
- ↑ "Muscarinic Receptor Agonists and Antagonists". Molecules 6 (3): 142–193. 2001. doi:10.3390/60300142. ISSN 1420-3049.
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