Chemistry:Anisodine
Anisodine, also known as daturamine and α-hydroxyscopolamine, is an antispasmodic and anticholinergic drug used in the treatment of acute circulatory shock in China.[1][2] It is a tropane alkaloid and is found naturally in plants of the family Solanaceae - notably Anisodus tanguticus (syn. Scopolia tangutica.[3][2] Anisodine acts as a muscarinic acetylcholine receptor antagonist and α1-adrenergic receptor antagonist.[1]
Compound medications
Anisodine/procaine is an injected prescription drug in China, approved for "ischemic optic nerve, retinal, and choroidal lesions". It is believed to work by reliving vascular spasms.[4]
Synthesis
(-)-Anisodine can be efficiently prepared using 6-beta-acetyltropine as the starting material via a key step of the Sharpless asymmetric dihydroxylation (AD).[3]
See also
- Anisodamine
- Scopolamine
References
- ↑ 1.0 1.1 "Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats". British Journal of Pharmacology 87 (3): 587–594. March 1986. doi:10.1111/j.1476-5381.1986.tb10201.x. PMID 2879586.
- ↑ 2.0 2.1 Dictionary of pharmacological agents - Google Books. CRC Press. 21 November 1996. ISBN 9780412466304. https://books.google.com/books?id=DeX7jgInYFMC&q=anisodine&pg=RA1-PA152.
- ↑ 3.0 3.1 "An efficient approach to the asymmetric total synthesis of (-)-anisodine". European Journal of Medicinal Chemistry 41 (3): 397–400. March 2006. doi:10.1016/j.ejmech.2005.12.001. PMID 16414152.
- ↑ "复方樟柳碱注射液说明书 [第五批化学药品说明书"]. https://www.nmpa.gov.cn/wwwroot/hy5/025.htm.
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