Chemistry:Anisodamine
From HandWiki
Short description: Chemical compound
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| Other names | 7β-hydroxyhyoscyamine |
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| Formula | C17H23NO4 |
| Molar mass | 305.374 g·mol−1 |
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Anisodamine, also known as 7β-hydroxyhyoscyamine, is an anticholinergic and α1 adrenergic receptor antagonist used in the treatment of acute circulatory shock in China .[1] It is given orally or by injection, as a racemic mixture (racanisodamine) or as a hydrobromide salt.[2] Eye drops at 0.5% concentration for slowing the progression of myopia is also available in China.[3]
Anisodamine is a naturally occurring tropane alkaloid found in some plants of the family Solanaceae including Datura.[4][5] Its Mandarin Chinese name 山莨菪碱 is given after Anisodus tanguticus (Chinese: 山莨菪; pinyin: shān làng dàng).[6]
See also
- Anisodine
- Atropine, used for similar cardiac and optamological purposes elsewhere
- Hyoscyamine
References
- ↑ "Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats". British Journal of Pharmacology 87 (3): 587–94. March 1986. doi:10.1111/j.1476-5381.1986.tb10201.x. PMID 2879586.
- ↑ "Pharmacopoeia Search: "山莨菪碱"". 中国药典. http://www.yaobiaozhun.com/yd2015/index.php?k=%E5%B1%B1%E8%8E%A8%E8%8F%AA%E7%A2%B1.
- ↑ "消旋山莨菪碱滴眼液防治少年儿童假性近视的疗效分析" (in zh-cn). 国际医药卫生导报 14 (15): 67–68. 2008. doi:10.3760/cma.j.issn.1007-1245.2008.15.027. http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_gjyywsdb200815027.
- ↑ "Simultaneous determination of atropine, scopolamine, and anisodamine in Flos daturae by capillary electrophoresis using a capillary coated by graphene oxide". Journal of Separation Science 36 (16): 2698–702. August 2013. doi:10.1002/jssc.201300304. PMID 23868645.
- ↑ "Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine". Neuroscience Letters 443 (3): 241–5. October 2008. doi:10.1016/j.neulet.2008.07.048. PMID 18672024.
- ↑ "消旋山莨菪碱" (in zh-CN). 中国药典. http://www.yaobiaozhun.com/yd2015/view.php?v=txt&id=4045.
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