Chemistry:Colforsin daropate
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number |
|
| PubChem CID | |
| ChemSpider | |
| UNII |
|
| KEGG |
|
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C27H43NO8 |
| Molar mass | 509.640 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Colforsin daropate is a carboxylic ester derived from the condensation of forskolin (colforsin) with N,N-dimethyl-β-alanine.[1]
Its water-soluble hydrochloride salt (NKH 477)[2] is an adenylyl cyclase activator which has been studied for its cardiac selectivity.[3][4]
Its parent compound forskolin (colforsin) is also used to raise levels of cAMP in the study of cell physiology.[5]
References
- ↑ "colforsin daropate". EMBL-EBI. https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:166826.
- ↑ "β-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-bpyran-6-yl ester, hydrochloride (1:1)"]. American Chemical Society. https://commonchemistry.cas.org/detail?cas_rn=138605-00-2.
- ↑ "Effect of NKH477, a new water-soluble forskolin derivative, on arterial-ventricular coupling and mechanical energy transduction in patients with left ventricular systolic dysfunction: comparison with dobutamine". J. Cardiovasc. Pharmacol. 24 (2): 310–6. August 1994. doi:10.1097/00005344-199424020-00018. PMID 7526066.
- ↑ "Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction". J. Pharmacol. Exp. Ther. 274 (1): 120–6. July 1995. PMID 7616388. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7616388.
- ↑ "Colforsin (Forskolin, HL 362) | ≥99%(HPLC) | Selleck | cAMP activator". https://www.selleckchem.com/products/forskolin.html.
 |  |
