Chemistry:Corymine
Corymine, also known as NSC381080, is a natural alkaloid found in Hunteria zeylanica.
This compound acts as a glycine antagonist and could therefore, be classed as a neurotoxin.
Occurrence
Corymine and many other indole alkaloids can be isolated from parts of the Hunteria zeylanica plant.
The plant also contains other similar alkaloids, such as[1]
- 3-epi-dihydrocorymine
- 3-epi-dihydrocorymine 3-acetate
- 3-epi-dihydrocorymine 17-acetate
- norisocorymine
Toxicity
Corymine and related alkaloids can act as convulsants.[2]
Tests on Xenopus occyte species have shown that corymine can decrease glycine's action at the inhibitory glycine receptors.[3] These same tests have revealed that Corymine can reduce the response of receptors to GABA,[3] the primary inhibitory neurotransmitter.
Other experiments have shown that corymine can potentiate convulsions induced by strychnine, a potent glycine antagonist.[4] This was also observed in mice.[5]
References
- ↑ "Alkaloids of Hunteria zeylanica". Phytochemistry 21 (2): 445–447. 1982-01-01. doi:10.1016/S0031-9422(00)95285-3. ISSN 0031-9422. Bibcode: 1982PChem..21..445L.
- ↑ "Corymine - Associated Disorders and Diseases" (in en). PubChem. U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/5379626.
- ↑ 3.0 3.1 "Inhibitory effects of corymine, an alkaloidal component from the leaves of Hunteria zeylanica, on glycine receptors expressed in Xenopus oocytes". European Journal of Pharmacology 332 (3): 321–326. August 1997. doi:10.1016/s0014-2999(97)01097-2. PMID 9300267.
- ↑ "A possible mechanism underlying corymine inhibition of glycine-induced Cl- current in Xenopus oocytes". European Journal of Pharmacology 348 (2–3): 271–277. May 1998. doi:10.1016/s0014-2999(98)00147-2. PMID 9652343.
- ↑ "Behavioral studies on alkaloids extracted from the leaves of Hunteria zeylanica". Biological & Pharmaceutical Bulletin 19 (3): 394–399. March 1996. doi:10.1248/bpb.19.394. PMID 8924908.
 |  |
