Chemistry:ORG-25935
From HandWiki
Short description: Synthetic drug
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| Formula | C21H25NO3 |
| Molar mass | 339.435 g·mol−1 |
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ORG-25935, also known as SCH-900435 is a synthetic drug developed by Organon International, which acts as a selective inhibitor of the glycine transporter GlyT-1. In animal tests it reduces alcohol consumption and has analgesic and anticonvulsant effects, but it has mainly been studied for its antipsychotic properties, and in human trials it was shown to effectively counteract the effects of the dissociative drug ketamine.[1][2][3][4][5][6][7][8]
See also
- Glycine reuptake inhibitor
References
- ↑ "The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats". Alcohol and Alcoholism 42 (1): 11–8. 2006. doi:10.1093/alcalc/agl085. PMID 17098748.
- ↑ "Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 130 (6): 458–63. December 2007. doi:10.1254/fpj.130.458. PMID 18079595.
- ↑ "The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens". Alcoholism: Clinical and Experimental Research 33 (7): 1151–7. July 2009. doi:10.1111/j.1530-0277.2009.00938.x. PMID 19389199.
- ↑ "Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test". Brain Research 1331: 105–13. May 2010. doi:10.1016/j.brainres.2010.03.032. PMID 20303337.
- ↑ "Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats". Biological Psychiatry 68 (8): 704–11. October 2010. doi:10.1016/j.biopsych.2010.05.029. PMID 20655511.
- ↑ "Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions". Journal of Neurochemistry 117 (3): 516–27. May 2011. doi:10.1111/j.1471-4159.2011.07223.x. PMID 21348870.
- ↑ "Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission". Psychopharmacology 221 (1): 115–31. May 2012. doi:10.1007/s00213-011-2554-3. PMID 22068461.
- ↑ "Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence". Neuropsychopharmacology 37 (4): 1036–46. March 2012. doi:10.1038/npp.2011.295. PMID 22113087.
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