Chemistry:Milacemide
From HandWiki
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| Names | |
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| IUPAC name
N2-Pentylglycinamide
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| Systematic IUPAC name
2-(Pentylamino)acetamide[1] | |
| Identifiers | |
3D model (JSmol)
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| ChEMBL | |
| ChemSpider | |
| MeSH | milacemide |
PubChem CID
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| UNII | |
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| Properties | |
| C7H16N2O | |
| Molar mass | 144.218 g·mol−1 |
| log P | 0.754 |
| Related compounds | |
Related compounds
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Tricine |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Milacemide (INN)[2] is an MAO-B inhibitor and glycine prodrug.[3] It has been studied for its effects on human memory and as a potential treatment for the symptoms of Alzheimer's disease.[4] Early clinical trials did not show positive results however,[3] and the drug is now abandoned and it is sold as a nonprescription drug or supplement. While milacemide is not an amino-acid, it acts similarly to glycine in the brain.[5]
References
- ↑ "milacemide - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 8 August 2005. Identifiers and Related Records. https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=53569&loc=ec_rcs.
- ↑ "International Nonproprietary Names for Pharmaceutical Substances. Supplement to WHO Chronicle, 1983, Vol. 37, No. 6 (December). Recommended International Nonproprietary Names (Rec. INN): List 23". World Health Organization. p. 6. https://www.who.int/medicines/publications/druginformation/innlists/RL23.pdf.
- ↑ 3.0 3.1 Dysken, MW; Mendels, J; LeWitt, P; Reisberg, B; Pomara, N; Wood, J; Skare, S; Fakouhi, JD et al. (May 1992). "Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type.". Journal of the American Geriatrics Society 40 (5): 503–6. doi:10.1111/j.1532-5415.1992.tb02019.x. PMID 1634705.
- ↑ Harris, Carol Turkington ; foreword by Joseph R. (2002). The encyclopedia of the brain and brain disorders (2nd ed.). New York, NY: Facts on File. ISBN 0-8160-4774-X. https://www.scribd.com/doc/10098801/The-Encyclopedia-of-the-Brain-and-Brain-Disorders. Retrieved 2017-09-10.
- ↑ Theodore I. Lidsky and Jay S. Schneider Phd, Brain Candy (2001). Brain Candy. New York, United States Of America: Simon & Schuster. ISBN 9780743218436. https://www.simonandschuster.co.uk/books/Brain-Candy/Theodore-Lidsky/9780743218436.
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