Chemistry:Coumermycin A1

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Short description: Chemical compound
Coumermycin A1
Coumermycin A1.svg
Clinical data
Other namesCoumamycin
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
Chemical and physical data
FormulaC55H59N5O20
Molar mass1110.092 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Coumermycin A1 is an aminocoumarin.[1][2] Its main target is the ATPase site of the DNA gyrase GyrB subunit.[3]

See also

References

  1. "Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins". Biotechnology Advances 27 (6): 1006–1014. 2009. doi:10.1016/j.biotechadv.2009.05.017. PMID 19463934. 
  2. "Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics". Current Topics in Medicinal Chemistry 8 (8): 667–79. 2008. doi:10.2174/156802608784221505. PMID 18473891. 
  3. "Structural Basis for DNA Gyrase Interaction with Coumermycin A1". Journal of Medicinal Chemistry 62 (8): 4225–4231. April 2019. doi:10.1021/acs.jmedchem.8b01928. PMID 30920824.