Chemistry:Dihydrouracil
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Dihydrouracil is an intermediate in the catabolism of uracil.[1] The enzyme dihydrouracil dehydrogenase (NAD+) converts uracil to dihydrouracil:
- REDIRECT Template:Chemical reaction
The enzyme uses reduced nicotinamide adenine dinucleotide (NADH) as its cofactor.[2][3]
Dihydrouracil is the base present in the nucleoside dihydrouridine.[4]
See also
References
- ↑ Nakamura, A; Kikuchi, K; Ohishi, T; Masuike, T (March 2004). "[Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].". Gan to Kagaku Ryoho. Cancer & Chemotherapy 31 (3): 381–6. PMID 15045945.
- ↑ "Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase". The Journal of Biological Chemistry 227 (2): 693–700. August 1957. doi:10.1016/S0021-9258(18)70749-7. PMID 13462991.
- ↑ West, Thomas P. (2001). "Pyrimidine base catabolism in Pseudomonas putida biotype B". Antonie van Leeuwenhoek 80 (2): 163–167. doi:10.1023/A:1012275512136. PMID 11759049.
- ↑ Dalluge, J.; Hashizume, T.; Sopchik, A. E.; McCloskey, J. A.; Davis, D. R. (1996). "Conformational flexibility in RNA: The role of dihydrouridine". Nucleic Acids Research 24 (6): 1073–1079. doi:10.1093/nar/24.6.1073. PMID 8604341.
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