Chemistry:Erlizumab
| Monoclonal antibody | |
|---|---|
| Type | F(ab')2 fragment |
| Source | Humanized (from mouse) |
| Target | CD18 |
| Clinical data | |
| ATC code |
|
| Identifiers | |
| CAS Number | |
| ChemSpider |
|
| UNII | |
| KEGG | |
  (what is this?) (verify) | |
Erlizumab, also known as rhuMAb, is a recombinant humanized monoclonal antibody that was an experimental immunosuppressive drug. Erlizumab was developed by Genentech under a partnership with Roche to treat heart attack, stroke, and traumatic shock.[1]
Mechanism of action
The drug works by blocking a growth factor in blood vessels.[2] Specifically, erlizumab targets CD18 and an LFA-1 integrin.[3] Erlizumab was meant to stop lymphocyte movement into inflamed tissue, thereby reducing tissue damage.[4]
Clinical trials
Genentech started clinical trials on the drug in October 1996.[5] During clinical trials, six patients suddenly started coughing up blood, and four of them later died.[2] In June 2000, preliminary phase II clinical trial results showed that erlizumab did not meet Genentech's goals.[1] Genentech's primary goal was for the drug to increase blood flow to the heart within 90 minutes of administering the medicine.[4]
Other anti-CD18 drugs
Multiple companies have tried to develop anti-CD18 drugs, but none of them have been successful.[4] Among them are Icos's rovelizumab (LeukArrest), and two drugs developed by Protein Design Labs and Centocor.[4] Although trials in humans have not gone well, the research of CD18 drugs in animals has been encouraging.[4] It is thought that the experimental medicines are affecting the lymphocyte adhesion pathway in humans in unintended ways.[4] One hypothesis is that the endothelial cell barrier function fails when blood supply is low for a prolonged time in humans.[6] If this is true, the drug is not able to stop lymphocyte movement into inflamed tissue.[6]
References
- ↑ 1.0 1.1 "Genentech Announces Phase II Trial of Experimental Anti-CD18 Antibody Did Not Meet Its Primary Objectives". Business Wire. June 16, 2000. http://findarticles.com/p/articles/mi_m0EIN/is_2000_June_16/ai_62759897.
- ↑ 2.0 2.1 Altman, Lawrence (May 30, 2000). "THE DOCTOR'S WORLD; In Search of Surprises as Cures for Cancer". The New York Times. https://query.nytimes.com/gst/fullpage.html?res=9E07E7DD163CF933A05756C0A9669C8B63.
- ↑ "Signalling via integrins: implications for cell survival and anticancer strategies". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1775 (1): 163–80. January 2007. doi:10.1016/j.bbcan.2006.09.001. PMID 17084981.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 "CD18 trials disappoint again". Nature Biotechnology 18 (8): 817–8. August 2000. doi:10.1038/78412. PMID 10932141.
- ↑ "Genentech Reports 1996 Third Quarter Results". Genentech. October 21, 1996. http://www.gene.com/gene/news/press-releases/display.do?method=detail&id=4805.
- ↑ 6.0 6.1 "Double-blind, randomized trial of an anti-CD18 antibody in conjunction with recombinant tissue plasminogen activator for acute myocardial infarction: limitation of myocardial infarction following thrombolysis in acute myocardial infarction (LIMIT AMI) study". Circulation 104 (23): 2778–83. December 2001. doi:10.1161/hc4801.100236. PMID 11733394.
 |  |
