Chemistry:Elsilimomab
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Short description: Monoclonal antibody
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Mouse |
| Target | IL-6 |
| Clinical data | |
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Elsilimomab (also known as B-E8) is a mouse monoclonal antibody.[1] B-E8 was developed by Diaclone,[2] a French company which produces many mouse monoclonal antibodies.
It (OPR-003) targets (and blocks) Interleukin-6.[3]
It has undergone a number of early stage clinical trials, e.g. for lymphoma and myeloma.[4]
It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339.[4]
References
- ↑ "WHO Drug Information". http://whqlibdoc.who.int/druginfo/INN_2004_list51.pdf. "p11:immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 k-chain, dimer"
- ↑ "Datasheet B-E8 mAb". Diaclone. https://www.diaclone.com/product/855.050.000-anti-human-il-6-azide-free/347.
- ↑ "First Fully Human Anti-IL6 Antibody Under Development". Genetic Engineering & Biotechnology News. Oct 2006. http://www.genengnews.com/gen-news-highlights/first-fully-human-anti-il6-antibody-under-development/6779735/.
- ↑ 4.0 4.1 "A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma". Clinical Cancer Research 15 (23): 7144–52. December 2009. doi:10.1158/1078-0432.CCR-09-1483. PMID 19934301.
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