Chemistry:Afelimomab
From HandWiki
Short description: Monoclonal antibody
| Monoclonal antibody | |
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| Type | F(ab')2 fragment |
| Source | Mouse |
| Target | TNFα |
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Afelimomab (MAK 195F) is an anti-TNFα monoclonal antibody. Administration of afelimomab reduces the concentration of interleukin-6 in patients with sepsis, but reduces mortality only marginally.[1][2]
References
- ↑ "Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels". Critical Care 9 (5): E20. August 2005. doi:10.1186/cc3798. PMID 16277704.
- ↑ "Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels". Critical Care Medicine 32 (11): 2173–82. November 2004. doi:10.1097/01.CCM.0000145229.59014.6C. PMID 15640628.
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