Chemistry:Priliximab
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Short description: Monoclonal antibody
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Chimeric (mouse/human) |
| Target | CD4 |
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Priliximab (cMT 412) is a human-mouse chimeric anti-CD4 monoclonal antibody. It has been tested on patients with Crohn's disease[1] and multiple sclerosis[2][3] but has not yet received U.S. Food and Drug Administration licensing. The patent belongs to the biotechnology company Centocor.
References
- ↑ "CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study". Gut 40 (3): 320–7. 1997. doi:10.1136/gut.40.3.320. PMID 9135519.
- ↑ "Effects of anti-CD4 antibody treatment on lymphocyte subsets and stimulated tumor necrosis factor alpha production: a study of 29 multiple sclerosis patients entered into a clinical trial of cM-T412". Neurology 48 (4): 810–6. 1997. doi:10.1212/wnl.48.4.810. PMID 9109860.
- ↑ "Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial". Neurology 49 (2): 351–7. 1997. doi:10.1212/wnl.49.2.351. PMID 9270561.
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