Chemistry:Gavilimomab
From HandWiki
Short description: Monoclonal antibody
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Mouse |
| Target | CD147 |
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Gavilimomab (also known as ABX-CBL) is a mouse monoclonal antibody intended for use as an immunosuppressive biologic treatment of glucocorticoid-resistant graft versus host disease. It binds to the antigen CD147.[1] Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy.[2]
It was originally developed by Abgenix,[1] which was later acquired by Amgen.
References
- ↑ 1.0 1.1 "Gavilimomab". Adis Insight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800006000.
- ↑ "A phase 2/3 multicenter randomized clinical trial of ABX-CBL versus ATG as secondary therapy for steroid-resistant acute graft-versus-host disease". Blood 109 (6): 2657–62. March 2007. doi:10.1182/blood-2006-08-013995. PMID 17110457.
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