Chemistry:Tildrakizumab

From HandWiki
Short description: Monoclonal antibody
Tildrakizumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
TargetInterleukin 23 (IL23)
Clinical data
Trade namesIlumya, Ilumetri
Other namesTildrakizumab-asmn; tildrakizumab
AHFS/Drugs.comMonograph
MedlinePlusa618026
License data
Pregnancy
category
  • AU: B1
Routes of
administration		Subcutaneous
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6426H9918N1698O2000S46
Molar mass144436.68 g·mol−1

Tildrakizumab, sold under the brand names Ilumya and Ilumetri, is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.[2] It is approved for the treatment of adult patients with moderate-to-severe plaque psoriasis in the United States and the European Union.[3][4][5]

Tildrakizumab was designed to block interleukin-23 (IL-23), a cytokine that plays a key role in managing the immune system and autoimmune disease.[6][7]

Medical use

Tildrakizumab was approved by the Food and Drug Administration in March 2018,[3] and the European Medicines Agency in September 2018, for the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy.[3][4]

Tildrakizumab is administered via subcutaneous injection. It is available as a single-dose prefilled syringe containing 100 mg of tildrakizumab in 1 mL of solution.[3][4]

History

The importance of IL-23 selective inhibition for the treatment of plaque psoriasis started to increase early after its identification in the year 2000, when it was found to be a crucial player in the pathogenesis of chronic immune diseases in general, and of psoriasis in particular. Based on that discovery, three monoclonal antibodies that selectively bind to IL-23p19 have been approved for the treatment of plaque psoriasis.[8]

Originally developed by Schering-Plough, this drug became part of Merck's clinical program, following that company's acquisition of Schering-Plough in 2009.[9]

In September 2014 Sun Pharmaceutical acquired worldwide rights to tildrakizumab for use in all human indications from Merck in exchange for an upfront payment of US$80 million. Upon product approval, Sun Pharmaceutical became responsible for regulatory activities, including subsequent submissions, pharmacovigilance, post approval studies, manufacturing and commercialization of the approved product.[10][11] In 2016, Sun Pharmaceutical signed a licensing agreement with the pharmaceutical company Almirall for marketing tildrakizumab in Europe.[11]

As of March 2014, the drug was in phase III clinical trials for plaque psoriasis. The two trials enrolled nearly 2000 patients.[12][13]

In 2016, tildrakizumab became the first IL-23p19 inhibitor to demonstrate positive results in Phase-3 clinical trials for the treatment of moderate-to-severe plaque psoriasis, further validating the importance of the role of IL-23 dependent pathways in psoriasis.[14] Later on, in 2019 the 3-year study results of continuous treatment with tildrakizumab were published. Given that psoriasis is a chronic disease that requires lifelong treatment, data on long-term maintenance of clinical responses and long-term safety are of special interest.[15]

Mechanism of action

Tildrakizumab is a humanized IgG1/k monoclonal antibody that selectively binds to the p19 subunit of the interleukin-23 (IL-23) cytokine and inhibits its interaction with the IL-23 receptor. IL-23 plays a critical role in modulating inflammatory and immune responses.[4]

Recent research has found the IL-23/Th17 pathway to be crucial for the pathogenic mechanisms of psoriasis,[7] with IL-23 considered the “master cytokine” since it acts at the top of the inflammatory pathway, activating the proliferation of pathogenic Th17 cells and subsequent production of proinflammatory cytokines, including IL-17.[6]

Structurally, IL-23 is a heterodimer with two subunits, p19 and p40. The p40 subunit is also shared with IL-12, a cytokine that is involved in the immune response. Treatments targeting the p40 subunit block both IL-23 and IL-12 and have been associated with an increased risk of infections.[16][6][7][17]

Tildrakizumab binds only to the p19 subunit of IL-23. Through this specific blockage, tildrakizumab inhibits the release of proinflammatory cytokines and chemokines that mediate epidermal hyperplasia, keratinocyte immune activation, and tissue inflammation inherent in psoriasis.[4][17]

Administration

Tildrakizumab is available as a single-use, pre-filled syringe and is administered via subcutaneous injection.[3][4]

The recommended dose of tildrakizumab in the United States and in the European Union is 100 mg at weeks 0, and 4 and every 12 weeks thereafter.[3][4] In the European Union, a 200 mg dose is also approved. For patients with certain characteristics (high disease burden, body weight ≥90 kg) the 200 mg may provide greater efficacy.[4]

Clinical trials

Tildrakizumab has been studied in around 1,800 patients in two double-blind, randomized and controlled Phase-3 trials, titled reSURFACE 1 and reSURFACE 2,[14] followed by a 4-year extension period.[14]

In the reSURFACE trials, a significantly higher proportion of patients receiving tildrakizumab achieved PASI 75 response at week 12 and a PGA score of “clear” or “minimal”, with at least a 2-grade reduction from baseline at week 12, than those in the placebo group (p<0.0001). Response continued to increase up to week 28 and was maintained through week 52.[14][15] Tildrakizumab was also proven to have superior efficacy to etanercept, an effective anti-TNFα treatment for psoriasis, with a significantly higher proportion of patients achieving PASI 75 and PASI 90 at weeks 12 and 28.[14] After 3 years of continued treatment with tildrakizumab, response levels were well maintained in week 28 responders: approximately 68% of patients maintained PASI 90 response and 91.6%, 79.8% and 51.9% maintained an absolute PASI of <5, <3, and <1, respectively (observed-cases data).[15]

Side effects

Safety differentiates anti-IL-23p19 treatments from other biologic treatments. There is a theoretical risk of infection and malignancy with the use of any immunosuppressant, including biologics. However, compared with the inhibition of other inflammatory cytokines, IL-23 targeting may only minimally impair the ability to generate a proper immune response.[6][16]

Tildrakizumab has proven to be a well-tolerated treatment in the long term.[15][16] The most common (≥ 1%) side effects associated with tildrakizumab treatment are upper respiratory infections, headache, gastroenteritis, nausea, diarrhoea, injection site pain, and back pain.[3][4] In the reSURFACE 1 and 2 clinical trials, the overall incidence of side effects was low and comparable to placebo.[14][16] Specifically, the incidence of severe infections, malignancies, and major adverse cardiovascular events was low and similar to that of placebo and etanercept treatment groups.[14]

Approvals and indications

In March 2018, it was approved by the Food and Drug Administration for the treatment of moderate-to-severe plaque psoriasis as an injection for subcutaneous use in the United States.[5] In September 2018, it was approved by the European Commission for the treatment of adult patients with moderate-to-severe chronic plaque psoriasis who are candidates for systemic therapy.[18]

References

  1. ↑ "Summary Basis of Decision (SBD) for Ilumya". 23 October 2014. https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?linkID=SBD00551&lang=en. 
  2. ↑ "Statement on a Nonproprietary Name Adopted by the USAN Council—Tildrakizumab", American Medical Association.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 ILUMYA™ Prescribing Information.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 ILUMETRI® Summary of Product Characteristics. Almirall, July 2019.
  5. ↑ 5.0 5.1 "FDA approves Ilumya for plaque psoriasis". National Psoriasis Foundation. March 22, 2018. https://www.psoriasis.org/advance/fda-approves-ilumya-plaque-psoriasis. 
  6. ↑ 6.0 6.1 6.2 6.3 "New anti-IL-23 drugs raise hopes for psoriasis plaque clearance". Nature Biotechnology 34 (12): 1218–1219. December 2016. doi:10.1038/nbt1216-1218. PMID 27926724. 
  7. ↑ 7.0 7.1 7.2 "Tildrakizumab for treating psoriasis". Expert Opinion on Biological Therapy 17 (5): 645–657. May 2017. doi:10.1080/14712598.2017.1304537. PMID 28271735. 
  8. ↑ "Targeting IL-23 in psoriasis: current perspectives". Psoriasis: Targets and Therapy 8: 1–5. 2018. doi:10.2147/PTT.S98893. PMID 29441315. 
  9. ↑ "Merck, Schering-Plough set to complete merger [Press release."]. Reuters. November 2009. https://www.reuters.com/article/us-merck-scheringplough-idUSTRE5A23YZ20091103. 
  10. ↑ "Sun Pharma and Merck & Co. Inc. Enter into Licensing Agreement for Tildrakizumab" (Press release). Merck. 17 September 2014. Archived from the original on 12 March 2015.
  11. ↑ 11.0 11.1 Bureau, BS B2B (28 July 2016). "Sun Pharma signs licensing pact with Spain's Almirall for tildrakizumab in Europe". Business Standard. BS B2B Bureau. https://www.business-standard.com/content/b2b-pharma/sun-pharma-signs-licensing-pact-with-spain-s-almirall-for-tildrakizumab-in-europe-116072800225_1.html. 
  12. ↑ Clinical trial number NCT01729754 for "A Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous Tildrakizumab (SCH 900222/MK-3222) in Participants With Moderate-to-Severe Chronic Plaque Psoriasis Followed by a Long-term Extension Study (MK-3222-011)" at ClinicalTrials.gov
  13. ↑ Clinical trial number NCT01722331 for "A Study to Evaluate the Efficacy and Safety of Subcutaneous MK-3222, Followed by an Optional Long-Term Safety Extension Study, in Participants with Moderate-to-Severe Chronic Plaque Psoriasis (MK-3222-010)" at ClinicalTrials.gov
  14. ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 "Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials". Lancet 390 (10091): 276–288. July 2017. doi:10.1016/S0140-6736(17)31279-5. PMID 28596043. 
  15. ↑ 15.0 15.1 15.2 15.3 "Long-term efficacy and safety of tildrakizumab for moderate-to-severe psoriasis: pooled analyses of two randomized phase III clinical trials (reSURFACE 1 and reSURFACE 2) through 148 weeks". The British Journal of Dermatology 182 (3): 605–617. March 2020. doi:10.1111/bjd.18232. PMID 31218661. 
  16. ↑ 16.0 16.1 16.2 16.3 "Tildrakizumab in the treatment of psoriasis: latest evidence and place in therapy". Therapeutic Advances in Chronic Disease 10: 2040622319865658. 2019. doi:10.1177/2040622319865658. PMID 31448070. 
  17. ↑ 17.0 17.1 "The role of IL 23 in the treatment of psoriasis". Expert Review of Clinical Immunology 13 (6): 525–534. June 2017. doi:10.1080/1744666X.2017.1292137. PMID 28165883. 
  18. ↑ "Almirall: The European Commission approves Almirall's ILUMETRI® (tildrakizumab) for moderate-to-severe chronic plaque psoriasis". 18 September 2018. https://m.marketscreener.com/ALMIRALL-SA-268048/news/Almirall-The-European-Commission-approves-Almirall-s-ILUMETRI-tildrakizumab-for-moderate-to-sev-27274802/. 

External links



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Tildrakizumab&oldid=3338475"