Chemistry:Toralizumab
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | CD40 ligand |
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Toralizumab (IDEC 131) was a humanized monoclonal antibody and an immunosuppressive drug. Possible indications included treatment of antibody-mediated disorders (immune thrombocytopenic purpura, lupus nephritis, rheumatoid arthritis), T-cell-mediated diseases (multiple sclerosis, Crohn's disease, and transplantations such as solid organ transplantation, pancreatic islet cell transplantation, and corneal transplantation), and B-cell malignancies such as CLL/small lymphocytic lymphoma, follicular cell lymphoma grade I or II, marginal zone lymphoma, mantle cell lymphoma, MALT lymphoma, Waldenström's macroglobulinemia, monocytoid B-cell lymphoma; relapsed/refractory Hodgkin's disease).[1]
In Phase II clinical trials regarding multiple sclerosis and Crohn's disease, thromboembolisms occurred in at least three patients. A causal connection could not be proven, but since the same adverse effects were seen in trials with a similar antibody (hu5C8), the trials were halted.[2]
The drug was developed by IDEC Pharmaceuticals Corporation.
References
- ↑ Statement On A Nonproprietary Name Adopted By The USAN Council - Toralizumab, American Medical Association.
- ↑ Immunotoxicology and immunopharmacology. Target Organ Toxicology Series (3rd ed.). Boca Raton, Florida: CRC Press, Taylor & Francis Group. 2007. p. 131. ISBN 978-0-8493-3790-1. https://books.google.com/books?id=L7G38ea2wnAC&q=Toralizumab&pg=PA131.
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