Chemistry:Odulimomab
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| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Mouse |
| Target | CD11a |
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Odulimomab is an investigational drug for the prevention of transplant rejection[1][2] and for the treatment of various immunological diseases.[3][4]
It is a mouse monoclonal antibody directed against the alpha chain of the protein lymphocyte function-associated antigen 1 which is involved in immune reactions.[1]
References
- ↑ 1.0 1.1 "Protective effect of an anti-LFA 1 monoclonal antibody (odulimomab) on renal damage due to ischemia and kidney autotransplantation". Transplantation Proceedings 32 (2): 481. March 2000. doi:10.1016/S0041-1345(00)00849-6. PMID 10715487.
- ↑ "[Role of calcineurin-dependent drugs on the immunosuppressive effect induced by the anti-LFA-1 antibody in a fetal intestinal transplantation model in mice]". Chirurgie; Mémoires de l'Académie de Chirurgie 124 (5): 503–10. November 1999. doi:10.1016/s0001-4001(00)88272-0. PMID 10615777.
- ↑ "Blocking ICAM-1 (CD54) and LFA-1 (CD11a) inhibits experimental allergic conjunctivitis". Clinical Immunology 93 (2): 107–13. November 1999. doi:10.1006/clim.1999.4775. PMID 10527686.
- ↑ "Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice". Transplantation 74 (1): 35–41. July 2002. doi:10.1097/00007890-200207150-00007. PMID 12134096.
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