Biology:CCRL2
 Generic protein structure example |
C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.[1][2] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.[3]
Function
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.[2]
References
- ↑ "Cloning and characterization of a novel human chemokine receptor". Biochem Biophys Res Commun 243 (1): 264–8. Mar 1998. doi:10.1006/bbrc.1997.7981. PMID 9473515.
- ↑ 2.0 2.1 "Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9034.
- ↑ "Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis". J. Exp. Med. 205 (10): 2207–20. September 2008. doi:10.1084/jem.20080300. PMID 18794339.
External links
- Human CCRL2 genome location and CCRL2 gene details page in the UCSC Genome Browser.
Further reading
- "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21.". Genomics 41 (2): 294–5. 1997. doi:10.1006/geno.1997.4626. PMID 9143512.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Galligan CL; Matsuyama W; Matsukawa A et al. (2004). "Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis". Arthritis Rheum. 50 (6): 1806–14. doi:10.1002/art.20275. PMID 15188357.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Muzny DM; Scherer SE; Kaul R et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997. Bibcode: 2006Natur.440.1194M.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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