Biology:Decoy receptor 2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily.[1][2][3]
Function
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain.
This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.[3]
References
- ↑ "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol 7 (12): 1003–6. Feb 1998. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.
- ↑ "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling". FEBS Lett 424 (1–2): 41–5. Apr 1998. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512. https://deepblue.lib.umich.edu/bitstream/2027.42/116376/1/feb2s0014579398001355.pdf.
- ↑ 3.0 3.1 "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8793.
Further reading
- "Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72. 2005. doi:10.1038/sj.cr.7290236. PMID 15538968.
- "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain.". Immunity 7 (6): 813–20. 1998. doi:10.1016/S1074-7613(00)80399-4. PMID 9430226.
- "TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege.". J. Immunol. 162 (10): 6053–9. 1999. doi:10.4049/jimmunol.162.10.6053. PMID 10229846.
- "Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells.". J. Immunol. 164 (8): 3961–70. 2000. doi:10.4049/jimmunol.164.8.3961. PMID 10754286.
- "Alternative functions for TRAIL receptors in eosinophils and neutrophils.". Swiss Medical Weekly 131 (17–18): 231–7. 2001. doi:10.4414/smw.2001.09707. PMID 11420819.
- "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain.". J. Neurosci. 22 (4): RC209. 2002. doi:10.1523/JNEUROSCI.22-04-j0001.2002. PMID 11844843.
- "The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells.". Cancer Res. 62 (8): 2430–6. 2002. PMID 11956107.
- "TRAIL induces death of human oligodendrocytes isolated from adult brain.". Brain 125 (Pt 11): 2469–80. 2002. doi:10.1093/brain/awf254. PMID 12390973.
- "Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival.". J. Immunol. 169 (10): 5986–96. 2003. doi:10.4049/jimmunol.169.10.5986. PMID 12421985.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction.". Diabetologia 45 (12): 1678–88. 2003. doi:10.1007/s00125-002-0926-2. PMID 12488957.
- "In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas.". Lab. Invest. 83 (6): 825–36. 2003. doi:10.1097/01.lab.0000073126.56932.46. PMID 12808117.
- "Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand.". J. Virol. 77 (17): 9156–72. 2003. doi:10.1128/JVI.77.17.9156-9172.2003. PMID 12915532.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.". Int. J. Cancer 109 (5): 786–92. 2004. doi:10.1002/ijc.20041. PMID 14999791.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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