Biology:Interleukin 11 receptor alpha subunit
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Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.[1]
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.[1]
References
Further reading
- "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11". Blood 86 (7): 2534–40. 1995. doi:10.1182/blood.V86.7.2534.bloodjournal8672534. PMID 7670098.
- "The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping". Genomics 32 (1): 49–53. 1996. doi:10.1006/geno.1996.0075. PMID 8786120.
- "Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13". Genomics 31 (1): 65–70. 1996. doi:10.1006/geno.1996.0010. PMID 8808281.
- "Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution". J. Biol. Chem. 273 (26): 16005–10. 1998. doi:10.1074/jbc.273.26.16005. PMID 9632650.
- "Identification of three distinct receptor binding sites of murine interleukin-11". J. Biol. Chem. 274 (9): 5755–61. 1999. doi:10.1074/jbc.274.9.5755. PMID 10026196.
- "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis". Eur. J. Biochem. 265 (2): 645–55. 1999. doi:10.1046/j.1432-1327.1999.00755.x. PMID 10504396.
- "Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma". Am. J. Pathol. 158 (1): 25–32. 2001. doi:10.1016/S0002-9440(10)63940-5. PMID 11141475.
- "Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro". Mol. Hum. Reprod. 8 (9): 841–8. 2003. doi:10.1093/molehr/8.9.841. PMID 12200462.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Expression and function of interleukin-11 and its receptor alpha in the human endometrium". Mol. Hum. Reprod. 9 (2): 75–80. 2003. doi:10.1093/molehr/gag012. PMID 12569176.
- "Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells". J. Biol. Chem. 279 (11): 10304–15. 2004. doi:10.1074/jbc.M312757200. PMID 14701802.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer". Cancer Res. 64 (2): 435–9. 2004. doi:10.1158/0008-5472.CAN-03-2675. PMID 14744752.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma". Leuk. Lymphoma 45 (11): 2315–9. 2005. doi:10.1080/10428190412331283161. PMID 15512823.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha". Ann. Oncol. 17 (1): 110–6. 2006. doi:10.1093/annonc/mdj064. PMID 16291580.
- "Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer". Ann. Surg. Oncol. 13 (6): 802–8. 2006. doi:10.1245/ASO.2006.05.028. PMID 16614887.
- "Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells". Int. J. Oncol. 29 (4): 869–76. 2006. doi:10.3892/ijo.29.4.869. PMID 16964382.
- "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells". Int. J. Oncol. 30 (4): 825–33. 2007. doi:10.3892/ijo.30.4.825. PMID 17332920.
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