Biology:Interleukin-7 receptor-α

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.

IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors.

Further reading

• "Role of interleukin-7 in T-cell development from hematopoietic stem cells.". Immunol. Rev. 165: 13–28. 1999. doi:10.1111/j.1600-065X.1998.tb01226.x. PMID 9850848. 
• Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis.". Cytokines Cell. Mol. Ther. 5 (1): 25–39. PMID 10390077. 
• "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.". Histol. Histopathol. 18 (3): 911–23. 2004. PMID 12792903. 
• Banham AH (2007). "Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells.". Trends Immunol. 27 (12): 541–4. doi:10.1016/j.it.2006.10.002. PMID 17045841. 
• "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13.". Leukemia 6 (7): 662–8. 1992. PMID 1378163. 
• "The interleukin-7 receptor gene is at 5p13.". Hum. Genet. 89 (5): 566–8. 1992. doi:10.1007/BF00219186. PMID 1634235. 
• "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.". Mol. Cell. Biol. 11 (6): 3052–9. 1991. doi:10.1128/MCB.11.6.3052. PMID 2038316. 
• "Activation of src family kinases in human pre-B cells by IL-7.". J. Immunol. 153 (1): 97–109. 1994. doi:10.4049/jimmunol.153.1.97. PMID 7515933. 
• "Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.". Leukemia 10 (8): 1317–25. 1996. PMID 8709637. 
• "Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice.". Cell 89 (7): 1011–9. 1997. doi:10.1016/S0092-8674(00)80289-5. PMID 9215624. 
• "Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor.". Nature 391 (6670): 904–7. 1998. doi:10.1038/36122. PMID 9495344. Bibcode: 1998Natur.391..904C. 
• "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.". Nat. Genet. 20 (4): 394–7. 1998. doi:10.1038/3877. PMID 9843216. 
• "Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor.". Immunity 11 (2): 213–23. 1999. doi:10.1016/S1074-7613(00)80096-5. PMID 10485656. 
• "Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha.". J. Biol. Chem. 275 (10): 7060–5. 2000. doi:10.1074/jbc.275.10.7060. PMID 10702271. 
• "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency.". Blood 96 (8): 2803–7. 2000. doi:10.1182/blood.V96.8.2803. PMID 11023514. 
• "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.". J. Immunol. 167 (1): 336–43. 2001. doi:10.4049/jimmunol.167.1.336. PMID 11418668. 

External links

• IL7R+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P16871 (Human Interleukin-7 receptor subunit alpha) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: P16872 (Mouse Interleukin-7 receptor subunit alpha) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.