Biology:Interleukin 27 receptor, alpha subunit
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Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.[1]
Function
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.[1]
Interactions
Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: IL27RA interleukin 27 receptor, alpha". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9466.
- ↑ "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. May 2003. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.
Further reading
- "Cloning and characterization of a novel class I cytokine receptor.". Biochem. Biophys. Res. Commun. 246 (1): 82–90. 1998. doi:10.1006/bbrc.1998.8576. PMID 9600072.
- "Development of Th1-type immune responses requires the type I cytokine receptor TCCR.". Nature 407 (6806): 916–20. 2000. doi:10.1038/35038103. PMID 11057672. Bibcode: 2000Natur.407..916C.
- "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.". Immunity 16 (6): 779–90. 2002. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
- "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.". J. Immunol. 170 (10): 4886–90. 2003. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.
- "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.". J. Immunol. 172 (4): 2225–31. 2004. doi:10.4049/jimmunol.172.4.2225. PMID 14764690.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.". Proc. Natl. Acad. Sci. U.S.A. 104 (47): 18502–7. 2008. doi:10.1073/pnas.0702388104. PMID 18003935.
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