Biology:Interferon gamma receptor 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.

Function

The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.

Interactions

Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.

Mutations

Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections. All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.

See also

• Cluster of differentiation
• Interferon-gamma receptor

Further reading

• "Antiviral actions of interferons". Clinical Microbiology Reviews 14 (4): 778–809, table of contents. Oct 2001. doi:10.1128/CMR.14.4.778-809.2001. PMID 11585785. 
• "High-affinity receptor for interferon-gamma (IFN-gamma), a ubiquitous protein occurring in different molecular forms on human cells: blood monocytes and eleven different cell lines have the same IFN-gamma receptor protein". Journal of Leukocyte Biology 49 (5): 462–73. May 1991. doi:10.1002/jlb.49.5.462. PMID 1826725. 
• "Human interferon gamma receptor 1 (IFNGR1) gene maps to chromosome region 6q23-6q24". Human Genetics 84 (1): 92–4. Dec 1989. doi:10.1007/BF00210682. PMID 2532616. 
• "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". The Journal of Biological Chemistry 262 (18): 8483–7. Jun 1987. doi:10.1016/S0021-9258(18)47439-X. PMID 2954953. 
• "Molecular cloning and expression of the human interferon-gamma receptor". Cell 55 (2): 273–80. Oct 1988. doi:10.1016/0092-8674(88)90050-5. PMID 2971451. 
• "Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133)". Journal of Immunology 155 (12): 5617–22. Dec 1995. doi:10.4049/jimmunol.155.12.5617. PMID 7499845. 
• "Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor". The Journal of Biological Chemistry 269 (20): 14333–6. May 1994. doi:10.1016/S0021-9258(17)36621-8. PMID 7514165. 
• "Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor". Nature 376 (6537): 230–5. Jul 1995. doi:10.1038/376230a0. PMID 7617032. Bibcode: 1995Natur.376..230W. 
• "Interaction between the components of the interferon gamma receptor complex". The Journal of Biological Chemistry 270 (36): 20915–21. Sep 1995. doi:10.1074/jbc.270.36.20915. PMID 7673114. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5". Biochemistry 33 (11): 3229–36. Mar 1994. doi:10.1021/bi00177a013. PMID 8136357. 
• "Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)". The EMBO Journal 13 (7): 1591–600. Apr 1994. doi:10.1002/j.1460-2075.1994.tb06422.x. PMID 8156998. 
• "Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity". Biochemistry 32 (9): 2423–30. Mar 1993. doi:10.1021/bi00060a038. PMID 8443182. 
• "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes". Science 259 (5102): 1739–42. Mar 1993. doi:10.1126/science.8456300. PMID 8456300. Bibcode: 1993Sci...259.1739D. 
• "Modulation of interferon-gamma receptor during human T lymphocyte alloactivation". European Journal of Immunology 23 (6): 1226–31. Jun 1993. doi:10.1002/eji.1830230605. PMID 8500521. 
• "A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection". The New England Journal of Medicine 335 (26): 1941–9. Dec 1996. doi:10.1056/NEJM199612263352602. PMID 8960473. 
• "Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection". The New England Journal of Medicine 335 (26): 1956–61. Dec 1996. doi:10.1056/NEJM199612263352604. PMID 8960475. 
• "Interferon-gamma induces biosynthesis of complement components C2, C4 and factor H by human proximal tubular epithelial cells". Cytokine 9 (4): 276–83. Apr 1997. doi:10.1006/cyto.1996.0164. PMID 9112336. 
• "Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex". Journal of Molecular Biology 273 (4): 882–97. Nov 1997. doi:10.1006/jmbi.1997.1336. PMID 9367779. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 

External links

• IFNGR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.