Biology:Interferon gamma receptor 1
Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene.[1][2][3]
Function
The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor.[1]
Interactions
Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.[4][5]
Mutations
Mutations in the IFNGR1 gene can lead to extreme susceptibility to Mycobacterial infections.[6][7] All known mutations and common variations in the IFNGR1 are present in the IFNGR1 mutation database.[8][9]
See also
References
- ↑ Jump up to: 1.0 1.1 "Entrez Gene: IFNGR1 interferon gamma receptor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3459.
- ↑ "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". The Journal of Biological Chemistry 262 (18): 8483–7. Jun 1987. doi:10.1016/S0021-9258(18)47439-X. PMID 2954953. http://www.jbc.org/cgi/reprint/262/18/8483.
- ↑ "Molecular cloning and expression of the human interferon-gamma receptor". Cell 55 (2): 273–80. Oct 1988. doi:10.1016/0092-8674(88)90050-5. PMID 2971451.
- ↑ "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex". Structure 8 (9): 927–36. Sep 2000. doi:10.1016/S0969-2126(00)00184-2. PMID 10986460.
- ↑ "Interaction between the components of the interferon gamma receptor complex". The Journal of Biological Chemistry 270 (36): 20915–21. Sep 1995. doi:10.1074/jbc.270.36.20915. PMID 7673114.
- ↑ Online Mendelian Inheritance in Man (OMIM) Immunodeficiency 27B; IMD27B -615978
- ↑ "Genetic deficiencies of innate immune signalling in human infectious disease". The Lancet. Infectious Diseases 9 (11): 688–98. 2009. doi:10.1016/S1473-3099(09)70255-5. PMID 19850227.
- ↑ "IFNGR1". LOVD database. https://www.lovd.nl/IFNGR1.
- ↑ "IFN-γR1 defects: Mutation update and description of the IFNGR1 variation database". Human Mutation 38 (10): 1286–1296. 2017. doi:10.1002/humu.23302. PMID 28744922.
Further reading
- "Antiviral actions of interferons". Clinical Microbiology Reviews 14 (4): 778–809, table of contents. Oct 2001. doi:10.1128/CMR.14.4.778-809.2001. PMID 11585785.
- "High-affinity receptor for interferon-gamma (IFN-gamma), a ubiquitous protein occurring in different molecular forms on human cells: blood monocytes and eleven different cell lines have the same IFN-gamma receptor protein". Journal of Leukocyte Biology 49 (5): 462–73. May 1991. doi:10.1002/jlb.49.5.462. PMID 1826725.
- "Human interferon gamma receptor 1 (IFNGR1) gene maps to chromosome region 6q23-6q24". Human Genetics 84 (1): 92–4. Dec 1989. doi:10.1007/BF00210682. PMID 2532616.
- "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". The Journal of Biological Chemistry 262 (18): 8483–7. Jun 1987. doi:10.1016/S0021-9258(18)47439-X. PMID 2954953.
- "Molecular cloning and expression of the human interferon-gamma receptor". Cell 55 (2): 273–80. Oct 1988. doi:10.1016/0092-8674(88)90050-5. PMID 2971451.
- "Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133)". Journal of Immunology 155 (12): 5617–22. Dec 1995. doi:10.4049/jimmunol.155.12.5617. PMID 7499845.
- "Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor". The Journal of Biological Chemistry 269 (20): 14333–6. May 1994. doi:10.1016/S0021-9258(17)36621-8. PMID 7514165.
- "Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor". Nature 376 (6537): 230–5. Jul 1995. doi:10.1038/376230a0. PMID 7617032. Bibcode: 1995Natur.376..230W.
- "Interaction between the components of the interferon gamma receptor complex". The Journal of Biological Chemistry 270 (36): 20915–21. Sep 1995. doi:10.1074/jbc.270.36.20915. PMID 7673114.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5". Biochemistry 33 (11): 3229–36. Mar 1994. doi:10.1021/bi00177a013. PMID 8136357.
- "Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)". The EMBO Journal 13 (7): 1591–600. Apr 1994. doi:10.1002/j.1460-2075.1994.tb06422.x. PMID 8156998.
- "Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity". Biochemistry 32 (9): 2423–30. Mar 1993. doi:10.1021/bi00060a038. PMID 8443182.
- "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes". Science 259 (5102): 1739–42. Mar 1993. doi:10.1126/science.8456300. PMID 8456300. Bibcode: 1993Sci...259.1739D.
- "Modulation of interferon-gamma receptor during human T lymphocyte alloactivation". European Journal of Immunology 23 (6): 1226–31. Jun 1993. doi:10.1002/eji.1830230605. PMID 8500521.
- "A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection". The New England Journal of Medicine 335 (26): 1941–9. Dec 1996. doi:10.1056/NEJM199612263352602. PMID 8960473.
- "Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection". The New England Journal of Medicine 335 (26): 1956–61. Dec 1996. doi:10.1056/NEJM199612263352604. PMID 8960475.
- "Interferon-gamma induces biosynthesis of complement components C2, C4 and factor H by human proximal tubular epithelial cells". Cytokine 9 (4): 276–83. Apr 1997. doi:10.1006/cyto.1996.0164. PMID 9112336.
- "Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex". Journal of Molecular Biology 273 (4): 882–97. Nov 1997. doi:10.1006/jmbi.1997.1336. PMID 9367779.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
External links
- IFNGR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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