Biology:Interleukin-27 receptor
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Short description: Type I cytokine receptor for interleukin-27
The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit[1][2] and glycoprotein 130.[3]
IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.[4]
References
- ↑ "Cloning and characterization of a novel class I cytokine receptor". Biochem. Biophys. Res. Commun. 246 (1): 82–90. 1998. doi:10.1006/bbrc.1998.8576. PMID 9600072.
- ↑ "Development of Th1-type immune responses requires the type I cytokine receptor TCCR". Nature 407 (6806): 916–20. 2000. doi:10.1038/35038103. PMID 11057672. Bibcode: 2000Natur.407..916C.
- ↑ "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27". Journal of Immunology 172 (4): 2225–31. February 2004. doi:10.4049/jimmunol.172.4.2225. PMID 14764690. http://www.jimmunol.org/cgi/content/abstract/172/4/2225.
- ↑ "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. May 2003. doi:10.4049/jimmunol.170.10.4886. PMID 12734330. http://www.jimmunol.org/cgi/content/abstract/170/10/4886.
External links
- Receptors,+Interleukin-27 at the US National Library of Medicine Medical Subject Headings (MeSH)
Original source: https://en.wikipedia.org/wiki/Interleukin-27 receptor.
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