Biology:Interleukin 8 receptor, beta
 Generic protein structure example |
Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.[1]
Function
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system (Gi/o-coupled[2]). This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands CXCL2, CXCL3, and CXCL5.
The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. IL8RB, IL8RA, which encodes another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.[3]
Mutations in CXCR2 cause hematological traits.[4]
Senescence
Knock-down studies involving the chemokine receptor CXCR2 alleviates both replicative and oncogene-induced senescence (OIS) and diminishes the DNA-damage response. Also, ectopic expression of CXCR2 results in premature senescence via a p53-dependent mechanism.[5]
See also
- Interleukin 8 receptor, alpha
- Interleukin 8
- Interleukin
- Interleukin receptor
- Cluster of differentiation
- G protein-coupled receptor
References
- ↑ "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics 14 (3): 685–91. Nov 1992. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896.
- ↑ "Entry in: gpDB, database of GPCRs, G-proteins, Effectors and their interactions". http://bioinformatics.biol.uoa.gr/gpDB/gpcrview.jsp?id=630.
- ↑ "Entrez Gene: IL8RB interleukin 8 receptor, beta". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3579.
- ↑ "Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits". Nature Genetics 46 (6): 629–34. Jun 2014. doi:10.1038/ng.2962. PMID 24777453.
- ↑ "Chemokine signaling via the CXCR2 receptor reinforces senescence". Cell 133 (6): 1006–18. Jun 2008. doi:10.1016/j.cell.2008.03.038. PMID 18555777.
Further reading
- "Platelet-derived CXC chemokines: old players in new games". Immunological Reviews 177: 204–16. Oct 2000. doi:10.1034/j.1600-065X.2000.17705.x. PMID 11138777.
- "Role of chemokines in the biology of natural killer cells". Journal of Leukocyte Biology 71 (2): 173–83. Feb 2002. doi:10.1189/jlb.71.2.173. PMID 11818437.
- "Molecular evolution of the human interleukin-8 receptor gene cluster". Nature Genetics 2 (1): 31–6. Sep 1992. doi:10.1038/ng0992-31. PMID 1303245. https://zenodo.org/record/1233397.
- "Characterization of two high affinity human interleukin-8 receptors". The Journal of Biological Chemistry 267 (23): 16283–7. Aug 1992. doi:10.1016/S0021-9258(18)41997-7. PMID 1379593.
- "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics 14 (3): 685–91. Nov 1992. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896.
- "Structure and functional expression of a human interleukin-8 receptor". Science 253 (5025): 1278–80. Sep 1991. doi:10.1126/science.1840701. PMID 1840701. Bibcode: 1991Sci...253.1278H.
- "Cloning of complementary DNA encoding a functional human interleukin-8 receptor". Science 253 (5025): 1280–3. Sep 1991. doi:10.1126/science.1891716. PMID 1891716. Bibcode: 1991Sci...253.1280M. https://zenodo.org/record/1230946.
- "Structure, genomic organization, and expression of the human interleukin-8 receptor B gene". The Journal of Biological Chemistry 269 (15): 11065–72. Apr 1994. doi:10.1016/S0021-9258(19)78092-2. PMID 7512557.
- "Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells". Journal of Leukocyte Biology 57 (1): 180–7. Jan 1995. doi:10.1002/jlb.57.1.180. PMID 7829970.
- "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B". The Journal of Biological Chemistry 269 (42): 26381–9. Oct 1994. doi:10.1016/S0021-9258(18)47205-5. PMID 7929358.
- "Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog". Science 265 (5172): 682–4. Jul 1994. doi:10.1126/science.8036519. PMID 8036519. Bibcode: 1994Sci...265..682C.
- "Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor". Gene 142 (2): 297–300. May 1994. doi:10.1016/0378-1119(94)90278-X. PMID 8194768.
- "Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B". Journal of Leukocyte Biology 55 (6): 763–70. Jun 1994. doi:10.1002/jlb.55.6.763. PMID 8195702.
- "Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells". The Journal of Biological Chemistry 269 (3): 1973–80. Jan 1994. doi:10.1016/S0021-9258(17)42123-5. PMID 8294449.
- "G protein-coupled signal transduction pathways for interleukin-8". Science 261 (5117): 101–3. Jul 1993. doi:10.1126/science.8316840. PMID 8316840. Bibcode: 1993Sci...261..101W.
- "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2". Molecular Immunology 30 (4): 359–67. Mar 1993. doi:10.1016/0161-5890(93)90065-J. PMID 8384312.
- "CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. Determinants of high affinity binding and receptor activation are distinct". The Journal of Biological Chemistry 271 (1): 225–32. Jan 1996. doi:10.1074/jbc.271.1.225. PMID 8550564.
- "Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket". The Journal of Biological Chemistry 271 (14): 8228–35. Apr 1996. doi:10.1074/jbc.271.14.8228. PMID 8626516.
- "Physical association of Gi2alpha with interleukin-8 receptors". The Journal of Biological Chemistry 271 (22): 12783–9. May 1996. doi:10.1074/jbc.271.22.12783. PMID 8662698.
- "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". The Journal of Biological Chemistry 271 (34): 20545–50. Aug 1996. doi:10.1074/jbc.271.34.20545. PMID 8702798.
External links
- CD182+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Chemokine Receptors: CXCR2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2212.
 |  |
