Biology:IFNB1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Interferon beta is a protein that in humans is encoded by the IFNB1 gene. The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.

Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

Further reading

• "Innate Immune Responses to LCMV Infections: Natural Killer Cells and Cytokines". Arenaviruses II. Current Topics in Microbiology and Immunology, vol. 263. 2002. pp. 7–27. doi:10.1007/978-3-642-56055-2_2. ISBN 978-3-642-62724-8. 
• "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.". Immunobiology 209 (1–2): 99–115. 2005. doi:10.1016/j.imbio.2004.02.008. PMID 15481145. 
• "Human interferons alpha, beta and omega". Growth Factors 22 (4): 243–51. 2005. doi:10.1080/08977190400000833. PMID 15621727. https://zenodo.org/record/1234455. 
• Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini Reviews in Medicinal Chemistry 5 (12): 1093–101. doi:10.2174/138955705774933383. PMID 16375755. 
• "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. 1991. PMID 1708818. 
• "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. 1991. doi:10.1016/S0021-9258(18)54862-6. PMID 1834641. 
• "On the relationship between human interferon alpha 1 and beta 1 genes". J. Interferon Res. 5 (3): 521–6. 1985. doi:10.1089/jir.1985.5.521. PMID 2414376. 
• "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306. 1988. doi:10.1016/0090-1229(88)90023-2. PMID 3135963. 
• "Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line". J. Biol. Chem. 262 (30): 14600–5. 1987. doi:10.1016/S0021-9258(18)47838-6. PMID 3667593. 
• "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. 1985. doi:10.1089/jir.1985.5.215. PMID 3872918. 
• "Isolation and structure of a human fibroblast interferon gene". Nature 285 (5766): 542–7. 1980. doi:10.1038/285542a0. PMID 6157094. Bibcode: 1980Natur.285..542D. 
• "The nucleotide sequence of human fibroblast interferon cDNA". Gene 10 (1): 11–5. 1980. doi:10.1016/0378-1119(80)90138-9. PMID 6157601. 
• "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase". Nucleic Acids Res. 8 (13): 2885–94. 1981. doi:10.1093/nar/8.13.2885. PMID 6159580. 
• "Synthesis of human fibroblast interferon by E. coli". Nucleic Acids Res. 8 (18): 4057–74. 1981. doi:10.1093/nar/8.18.4057. PMID 6159584. 
• "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers". Nucleic Acids Res. 8 (9): 1913–31. 1981. doi:10.1093/nar/8.9.1913. PMID 6159597. 
• Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon". Nature 289 (5798): 606–7. doi:10.1038/289606a0. PMID 6162107. Bibcode: 1981Natur.289..606W. 
• "Human fibroblast interferon gene lacks introns". Nucleic Acids Res. 9 (5): 1045–52. 1981. doi:10.1093/nar/9.5.1045. PMID 6164984. 
• "A single amino acid change in IFN-beta1 abolishes its antiviral activity". Nature 294 (5841): 563–5. 1982. doi:10.1038/294563a0. PMID 6171735. 
• "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768–72. 1982. doi:10.1073/pnas.79.9.2768. PMID 6178110. Bibcode: 1982PNAS...79.2768C. 
• "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells". Philos. Trans. R. Soc. Lond. B Biol. Sci. 299 (1094): 29–38. 1983. doi:10.1098/rstb.1982.0103. PMID 6183692.