Biology:Pesticide

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Short description: Substance used to destroy pests
A crop-duster spraying pesticide on a field
A self-propelled crop sprayer spraying pesticide on a field

Pesticides are substances that are used to control pests.[1] They include herbicides, insecticides, nematicides, fungicides, and many others (see table).[2] The most common of these are herbicides, which account for approximately 50% of all pesticide use globally.[3] Most pesticides are used as plant protection products (also known as crop protection products), which in general protect plants from weeds, fungi, or insects. In general, a pesticide is a chemical or biological agent (such as a virus, bacterium, or fungus) that deters, incapacitates, kills, or otherwise discourages pests. Target pests can include insects, plant pathogens, weeds, molluscs, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisance, or spread disease, or are disease vectors. Along with these benefits, pesticides also have drawbacks, such as potential toxicity to humans and other species.


Definition

Type of pesticide Target pest group
Algicides or algaecides Algae
Avicides Birds
Bactericides Bacteria
Fungicides Fungi and oomycetes
Herbicides Plant
Insecticides Insects
Lampricides Lampreys[4]
Miticides or acaricides Mites
Molluscicides Snails
Nematicides Nematodes
Rodenticides Rodents
Slimicides Algae, Bacteria, Fungi, and Slime molds
Virucides Viruses

The word pesticide derives from the Latin pestis (plague) and caedere (kill).[5]

The Food and Agriculture Organization (FAO) has defined pesticide as:

any substance or mixture of substances intended for preventing, destroying, or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals, causing harm during or otherwise interfering with the production, processing, storage, transport, or marketing of food, agricultural commodities, wood and wood products or animal feedstuffs, or substances that may be administered to animals for the control of insects, arachnids, or other pests in or on their bodies. The term includes substances intended for use as a plant growth regulator, defoliant, desiccant, or agent for thinning fruit or preventing the premature fall of fruit. Also used as substances applied to crops either before or after harvest to protect the commodity from deterioration during storage and transport.[6]

Classifications

Pesticides can be classified by target organism (e.g., herbicides, insecticides, fungicides, rodenticides, and pediculicides – see table),[7]

Biopesticides according to the EPA include microbial pesticides, biochemical pesticides, and plant-incorporated protectants.[8]

Pesticides can be classified into structural classes, with many structural classes developed for each of the target organisms listed and linked in the table above. A structural class is usually associated with a single mode of action, whereas a mode of action may encompass more than one structural class.

The pesticidal chemical (active ingredient) is mixed (formulated) with other components to form the product that is sold, and which is applied in various ways. Pesticides in gas form are fumigants.

Pesticides can be classified based upon their mode of action, which indicates the exact biological mechanism which the pesticide disrupts. The modes of action are important for resistance management, and are categorized and administered by the insecticide, herbicide, and fungicide resistance action committees.

Pesticides may be systemic or non-systemic.[9][10] A systemic pesticide moves (translocates) inside the plant. Translocation may be upward in the xylem, or downward in the phloem or both. Non-systemic pesticides (contact pesticides) remain on the surface and act though direct contact with target organism. Pesticdes are more effective if they are systemic. Systemicity is a prerequisite for the pesticide to be used as a seed-treatment.

Pesticides can be classified as persistent (non-biodegradable) or non-persistent (biodegradable). A pesticide must be persistent enough to kill or control its target but must degrade fast enough not to accumulate in the environment or the food chain in order to be approved by the authorities.[11][12] Persistent pesticides, including DDT, were banned decades ago, an exception being spraying in houses to combat malaria vectors.[13]

History

Since before 2000 BC, humans have utilized pesticides to protect their crops. The first known pesticide was elemental sulfur dusting used in Sumer about 4,500 years ago in ancient Mesopotamia.[14] By the 15th century, toxic chemicals such as arsenic, mercury, and lead were being applied to crops to kill pests. In the 17th century, nicotine sulfate was extracted from tobacco leaves for use as an insecticide. The 19th century saw the introduction of two more natural pesticides, pyrethrum, which is derived from chrysanthemums, and rotenone, which is derived from the roots of tropical vegetables.[15] Until the 1950s, arsenic-based pesticides (such as calcium arsenate, lead arsenate and Paris green) were dominant.[16] Paul Müller discovered that DDT was a very effective insecticide. Chlorinates such as DDT were dominant, but they were replaced in the U.S. by organophosphates and carbamates by 1975. Since then, pyrethroids have become the dominant insecticide.[16] Herbicides became common in the 1960s, led by "triazine and other nitrogen-based compounds, carboxylic acids such as 2,4-dichlorophenoxyacetic acid, and glyphosate".[16]

The first legislation providing federal authority for regulating pesticides was enacted in 1910.[17] During the 1940s, manufacturers produced large amounts of synthetic pesticides and their use became widespread.[18] Before the first World War, Germany was the world's leading chemical industry and exported most of the dyes and other chemicals that were used in the United States. War implemented tariffs that stimulated the growth of the chemical industry in the U.S., which made chemistry a prestigious occupation as this industry expanded and became profitable. Money and ideas flowed back from Europe after the U.S. entered WWI, changing the way Americans interacted with themselves and nature, and the industrialization of war hastened the industrialization of pest control.[19] Some sources consider the 1940s and 1950s to have been the start of the "pesticide era."[20] Although the U.S. Environmental Protection Agency was established in 1970 and amendments to the pesticide law in 1972,[17] pesticide use has increased 50-fold since 1950 and 2.3 million tonnes (2.5 million short tons) of industrial pesticides are now[when?] used each year.[15] Seventy-five percent of all pesticides in the world are used in developed countries, but use in developing countries is increasing.[21] A study of USA pesticide use trends through 1997 was published in 2003 by the National Science Foundation's Center for Integrated Pest Management.[16][22]

In the 1960s, it was discovered that DDT was preventing many fish-eating birds from reproducing, which was a serious threat to biodiversity. Rachel Carson wrote the best-selling book Silent Spring about biological magnification. The agricultural use of DDT is now banned under the Stockholm Convention on Persistent Organic Pollutants, which allowed as an exception spraying on interior walls to kill or repel mosquitoes to prevent malaria and other tropical diseases.[13]

Development of new pesticides

The aim is to find new compounds or agents with improved properties such as a new mode of action or lower application rate. Another aim is to replace older pesticides which have been banned for reasons of toxicity or environmental harm or have become less effective due to development of resistance.[23][24][25][26]

The process starts with testing (screening) against target organisms such as insects, fungi or plants. Inputs are typically random compounds, natural products,[27] compounds designed to disrupt a biochemical target, compounds described in patents or literature, or biocontrol organisms.

Compounds that are active in the screening process, known as hits or leads, cannot be used as pesticides, except for biocontrol organisms and some potent natural products. These lead compounds need to be optimised by a series of cycles of synthesis and testing of analogs. For approval by regulatory authorities for use as pesticides, the optimized compounds must meet several requirements.[11][12] In addition to being potent (low application rate), they must show low toxicity, low environmental impact, and viable manufacturing cost. The cost of developing a pesticide in 2022 was estimated to be 350 million US dollars.[28]

More than 25% of existing chemical pesticides contain one or more chiral centres (stereogenic centres).[29] Newer pesticides with lower application rates tend to have more complex structures, and thus more often contain chiral centres.[29] In cases when most or all of the pesticidal activity in a new compound is found in one enantiomer (the eutomer), the registration and use of the compound as this single enantiomer is preferred. This reduces the total application rate and avoids the tedious environmental testing required when registering a racemate.[30][31] However if a viable enantioselective manufacturing route cannot be found, then the racemate is registered and used.

Insecticides with systemic activity against sucking pests, which are safe to pollinators, are sought after,[32][28][23] particularly in view of the partial bans on neonicotinoids. Revised 2023 guidance by registration authorities describes the bee testing that is required for new insecticides to be approved for commercial use.[33][34][35][36]

Uses

Pesticide use worldwide, by country in 2021

In addition to their main use in agriculture, pesticides have a number of other applications. Pesticides are used to control organisms that are considered to be harmful, or pernicious to their surroundings.[37] For example, they are used to kill mosquitoes that can transmit potentially deadly diseases like West Nile virus, yellow fever, and malaria. They can also kill bees, wasps or ants that can cause allergic reactions. Insecticides can protect animals from illnesses that can be caused by parasites such as fleas.[37] Pesticides can prevent sickness in humans that could be caused by moldy food or diseased produce. Herbicides can be used to clear roadside weeds, trees, and brush. They can also kill invasive weeds that may cause environmental damage. Herbicides are commonly applied in ponds and lakes to control algae and plants such as water grasses that can interfere with activities like swimming and fishing and cause the water to look or smell unpleasant.[38] Uncontrolled pests such as termites and mold can damage structures such as houses.[37] Pesticides are used in grocery stores and food storage facilities to manage rodents and insects that infest food such as grain. Pesticides are used on lawns and golf courses, partly for cosmetic reasons.[39]

Integrated pest management, the use of multiple approaches to control pests, is becoming widespread and has been used with success in countries such as Indonesia, China , Bangladesh, the U.S., Australia , and Mexico.[21] IPM attempts to recognize the more widespread impacts of an action on an ecosystem, so that natural balances are not upset.[18]

Each use of a pesticide carries some associated risk. Proper pesticide use decreases these associated risks to a level deemed acceptable by pesticide regulatory agencies such as the United States Environmental Protection Agency (EPA) and the Pest Management Regulatory Agency (PMRA) of Canada.

DDT, sprayed on the walls of houses, is an organochlorine that has been used to fight malaria vectors (mosquitos) since the 1940s. The World Health Organization recommend this approach.[40] It and other organochlorine pesticides have been banned in most countries worldwide because of their persistence in the environment and human toxicity. DDT has become less effective, as resistance was identified in Africa as early as 1955, and by 1972 nineteen species of mosquito worldwide were resistant to DDT.[41][42]

Amount used

Pesticide use by region

Total pesticides use in agriculture in 2021 was 3.54 million tonnes of active ingredients (Mt), a 4 percent increase with respect to 2020, a 11 percent increase in a decade, and a doubling since 1990. Pesticides use per area of cropland in 2021 was 2.26 kg per hectare (kg/ha), an increase of 4 percent with respect to 2020; use per value of agricultural production was 0.86 kg per thousand international dollar (kg/1000 I$) (+2%); and use per person was 0.45 kg per capita (kg/cap) (+3%). Between 1990 and 2021, these indicators increased by 85 percent, 3 percent, and 33 percent, respectively. Brazil was the world’s largest user of pesticides in 2021, with 720 kt of pesticides applications for agricultural use, while USA (457 kt) was the second largest user.[43][44]

Pesticides are also found in majority of U.S. households with 88 million out of the 121.1 million households indicating that they use some form of pesticide in 2012.[45][46] As of 2007, there were more than 1,055 active ingredients registered as pesticides,[17] which yield over 20,000 pesticide products that are marketed in the United States.[47]

Applications per cropland area in 2021 varied widely, from 10.9 kg/hectare in Brazil to 0.8 kg/ha in the Russian Federation. The level in Brazil was about twice as high as in Argentina (5.6 kg/ha) and Indonesia (5.3 kg/ha).[43] Insecticide use in the US has declined by more than half since 1980 (0.6%/yr), mostly due to the near phase-out of organophosphates. In corn fields, the decline was even steeper, due to the switchover to transgenic Bt corn.[48]

Benefits

Pesticides can save farmers' money by preventing crop losses to insects and other pests; in the U.S., farmers get an estimated fourfold return on money they spend on pesticides.[49] One study found that not using pesticides reduced crop yields by about 10%.[50] Another study, conducted in 1999, found that a ban on pesticides in the United States may result in a rise of food prices, loss of jobs, and an increase in world hunger.[51]

There are two levels of benefits for pesticide use, primary and secondary. Primary benefits are direct gains from the use of pesticides and secondary benefits are effects that are more long-term.[52]

Biological

Controlling pests and plant disease vectors

  • Improved crop yields
  • Improved crop/livestock quality
  • Invasive species controlled

Controlling human/livestock disease vectors and nuisance organisms

  • Human lives saved and disease reduced. Diseases controlled include malaria,[52] with millions of lives having been saved or enhanced with the use of DDT alone.[53]
  • Animal lives saved and disease reduced

Controlling organisms that harm other human activities and structures

  • Drivers view unobstructed
  • Tree/brush/leaf hazards prevented
  • Wooden structures protected[52]

Monetary

In one study, it was estimated that for every dollar ($1) that is spent on pesticides for crops can yield up to four dollars ($4) in crops saved.[54] This means based that, on the amount of money spent per year on pesticides, $10 billion, there is an additional $40 billion savings in crop that would be lost due to damage by insects and weeds. In general, farmers benefit from having an increase in crop yield and from being able to grow a variety of crops throughout the year. Consumers of agricultural products also benefit from being able to afford the vast quantities of produce available year-round.[52]

Disadvantages

On the cost side of pesticide use there can be costs to the environment, costs to human health.[55] Pesticides safety education and pesticide applicator regulation are designed to protect the public from pesticide misuse, but do not eliminate all misuse. Reducing the use of pesticides and choosing less toxic pesticides may reduce risks placed on society and the environment from pesticide use.[38]

Health effects

Main page: Medicine:Health effects of pesticides
A sign warning about potential pesticide exposure

Pesticides may cause acute and delayed health effects in people who are exposed.[56] Pesticide exposure can cause a variety of adverse health effects, ranging from simple irritation of the skin and eyes to more severe effects such as affecting the nervous system, hearing,[57] mimicking hormones causing reproductive problems, and also causing cancer.[58] A 2007 systematic review found that "most studies on non-Hodgkin lymphoma and leukemia showed positive associations with pesticide exposure" and thus concluded that cosmetic use of pesticides should be decreased.[59] There is substantial evidence of associations between organophosphate insecticide exposures and neurobehavioral alterations.[60][61][62][63] Limited evidence also exists for other negative outcomes from pesticide exposure including neurological, birth defects, and fetal death.[64]

The American Academy of Pediatrics recommends limiting exposure of children to pesticides and using safer alternatives:[65]

Owing to inadequate regulation and safety precautions, 99% of pesticide-related deaths occur in developing countries that account for only 25% of pesticide usage.[66]

One study found pesticide self-poisoning the method of choice in one third of suicides worldwide, and recommended, among other things, more restrictions on the types of pesticides that are most harmful to humans.[67]

A 2014 epidemiological review found associations between autism and exposure to certain pesticides, but noted that the available evidence was insufficient to conclude that the relationship was causal.[68]

Occupational exposure among agricultural workers

The World Health Organization and the UN Environment Programme estimate that 3 million agricultural workers in the developing world experience severe poisoning from pesticides each year, resulting in 18,000 deaths.[21] According to one study, as many as 25 million workers in developing countries may suffer mild pesticide poisoning yearly.[69] Other occupational exposures besides agricultural workers, including pet groomers, groundskeepers, and fumigators, may also put individuals at risk of health effects from pesticides.[47]

Pesticide use is widespread in Latin America, as around US$3 billion are spent each year in the region. Records indicate an increase in the frequency of pesticide poisonings over the past two decades. The most common incidents of pesticide poisoning is thought to result from exposure to organophosphate and carbamate insecticides.[70] At-home pesticide use, use of unregulated products, and the role of undocumented workers within the agricultural industry makes characterizing true pesticide exposure a challenge. It is estimated that 50–80% of pesticide poisoning cases are unreported.

Underreporting of pesticide poisoning is especially common in areas where agricultural workers are less likely to seek care from a healthcare facility that may be monitoring or tracking the incidence of acute poisoning. The extent of unintentional pesticide poisoning may be much greater than available data suggest, particularly among developing countries. Globally, agriculture and food production remain one of the largest industries. In East Africa, the agricultural industry represents one of the largest sectors of the economy, with nearly 80% of its population relying on agriculture for income.[71] Farmers in these communities rely on pesticide products to maintain high crop yields.

Some East Africa governments are shifting to corporate farming, and opportunities for foreign conglomerates to operate commercial farms have led to more accessible research on pesticide use and exposure among workers. In other areas where large proportions of the population rely on subsistence, small-scale farming, estimating pesticide use and exposure is more difficult.

Pesticide poisoning

The cholinergic synapse and the breakdown of acetylcholine into choline and acetate by acetylcholinesterase

Pesticides may exhibit toxic effects on humans and other non-target species, the severity of which depends on the frequency and magnitude of exposure. Toxicity also depends on the rate of absorption, distribution within the body, metabolism, and elimination of compounds from the body. Commonly used pesticides like organophosphates and carbamates act by inhibiting acetylcholinesterase activity, which prevents the breakdown of acetylcholine at the neural synapse. Excess acetylcholine can lead to symptoms like muscle cramps or tremors, confusion, dizziness and nausea. Studies show that farm workers in Ethiopia, Kenya, and Zimbabwe have decreased concentrations of plasma acetylcholinesterase, the enzyme responsible for breaking down acetylcholine acting on synapses throughout the nervous system.[72][73][74] Other studies in Ethiopia have observed reduced respiratory function among farm workers who spray crops with pesticides.[75] Numerous exposure pathways for farm workers increase the risk of pesticide poisoning, including dermal absorption walking through fields and applying products, as well as inhalation exposure.

Measuring exposure to pesticides

There are multiple approaches to measuring a person's exposure to pesticides, each of which provides an estimate of an individual's internal dose. Two broad approaches include measuring biomarkers and markers of biological effect.[76] The former involves taking direct measurement of the parent compound or its metabolites in various types of media: urine, blood, serum. Biomarkers may include a direct measurement of the compound in the body before it's been biotransformed during metabolism. Other suitable biomarkers may include the metabolites of the parent compound after they've been biotransformed during metabolism.[76] Toxicokinetic data can provide more detailed information on how quickly the compound is metabolized and eliminated from the body, and provide insights into the timing of exposure.

Markers of biological effect provide an estimation of exposure based on cellular activities related to the mechanism of action. For example, many studies investigating exposure to pesticides often involve the quantification of the acetylcholinesterase enzyme at the neural synapse to determine the magnitude of the inhibitory effect of organophosphate and carbamate pesticides.[72][73][74][76]

Another method of quantifying exposure involves measuring, at the molecular level, the amount of pesticide interacting with the site of action. These methods are more commonly used for occupational exposures where the mechanism of action is better understood, as described by WHO guidelines published in "Biological Monitoring of Chemical Exposure in the Workplace".[77] Better understanding of how pesticides elicit their toxic effects is needed before this method of exposure assessment can be applied to occupational exposure of agricultural workers.

Alternative methods to assess exposure include questionnaires to discern from participants whether they are experiencing symptoms associated with pesticide poisoning. Self-reported symptoms may include headaches, dizziness, nausea, joint pain, or respiratory symptoms.[73]

Challenges in assessing pesticide exposure

Multiple challenges exist in assessing exposure to pesticides in the general population, and many others that are specific to occupational exposures of agricultural workers. Beyond farm workers, estimating exposure to family members and children presents additional challenges, and may occur through "take-home" exposure from pesticide residues collected on clothing or equipment belonging to parent farm workers and inadvertently brought into the home. Children may also be exposed to pesticides prenatally from mothers who are exposed to pesticides during pregnancy.[60] Characterizing children's exposure resulting from drift of airborne and spray application of pesticides is similarly challenging, yet well documented in developing countries.[78] Because of critical development periods of the fetus and newborn children, these non-working populations are more vulnerable to the effects of pesticides, and may be at increased risk of developing neurocognitive effects and impaired development.[60][66]

While measuring biomarkers or markers of biological effects may provide more accurate estimates of exposure, collecting these data in the field is often impractical and many methods are not sensitive enough to detect low-level concentrations. Rapid cholinesterase test kits exist to collect blood samples in the field. Conducting large scale assessments of agricultural workers in remote regions of developing countries makes the implementation of these kits a challenge.[76] The cholinesterase assay is a useful clinical tool to assess individual exposure and acute toxicity. Considerable variability in baseline enzyme activity among individuals makes it difficult to compare field measurements of cholinesterase activity to a reference dose to determine health risk associated with exposure.[76] Another challenge researchers face in deriving a reference dose is identifying health endpoints that are relevant to exposure. More epidemiological research is needed to identify critical health endpoints, particularly among populations who are occupationally exposed.

Prevention

Minimizing harmful exposure to pesticides can be achieved by proper use of personal protective equipment, adequate reentry times into recently sprayed areas, and effective product labeling for hazardous substances as per FIFRA regulations. Training high-risk populations, including agricultural workers, on the proper use and storage of pesticides, can reduce the incidence of acute pesticide poisoning and potential chronic health effects associated with exposure. Continued research into the human toxic health effects of pesticides serves as a basis for relevant policies and enforceable standards that are health protective to all populations.

Environmental effects

Pesticide use raises a number of environmental concerns. Over 98% of sprayed insecticides and 95% of herbicides reach a destination other than their target species, including non-target species, air, water and soil.[21] Pesticide drift occurs when pesticides suspended in the air as particles are carried by wind to other areas, potentially contaminating them. Pesticides are one of the causes of water pollution, and some pesticides were persistent organic pollutants (now banned), which contribute to soil and flower (pollen, nectar) contamination.[79] Furthermore, pesticide use can adversely impact neighboring agricultural activity, as pests themselves drift to and harm nearby crops that have no pesticide used on them.[80]

In addition, pesticide use reduces biodiversity, contributes to pollinator decline,[81][82][83] destroys habitat (especially for birds),[84] and threatens endangered species.[21] Pests can develop a resistance to the pesticide (pesticide resistance), necessitating a new pesticide. Alternatively a greater dose of the pesticide can be used to counteract the resistance, although this will cause a worsening of the ambient pollution problem.

The Stockholm Convention on Persistent Organic Pollutants, banned all persistent pesticides,[85][86] in particular DDT and other organochlorine pesticides, which were stable and lipophilic, and thus able to bioaccumulate[87] in the body and the food chain. and which spread throughout the planet.[88][89] Persistent pesticides are no longer used for agriculture, and will not be approved by the authorities.[11][12] Because the half life in soil is long (for DDT 2-15 years[90]) residues can still be detected in humans at levels 5 to 10 times lower than found in the 1970s.[91]

Pesticides now have to be degradable in the environment. Such degradation of pesticides is due to both innate chemical properties of the compounds and environmental processes or conditions.[92] For example, the presence of halogens within a chemical structure often slows down degradation in an aerobic environment.[93] Adsorption to soil may retard pesticide movement, but also may reduce bioavailability to microbial degraders.[94]

Pesticide contamination in the environment can be monitored through bioindicators such as bee pollinators.[79]

Economics

Harm Annual US cost
Public health $1.1 billion
Pesticide resistance in pest $1.5 billion
Crop losses caused by pesticides $1.4 billion
Bird losses due to pesticides $2.2 billion
Groundwater contamination $2.0 billion
Other costs $1.4 billion
Total costs $9.6 billion

In one study, the human health and environmental costs due to pesticides in the United States was estimated to be $9.6 billion: offset by about $40 billion in increased agricultural production.[95]

Additional costs include the registration process and the cost of purchasing pesticides: which are typically borne by agrichemical companies and farmers respectively. The registration process can take several years to complete (there are 70 different types of field tests) and can cost $50–70 million for a single pesticide.[95] At the beginning of the 21st century, the United States spent approximately $10 billion on pesticides annually.[95]

Resistance

Main page: Biology:Pesticide resistance

The use of pesticides inherently entails the risk of resistance developing. Various techniques and procedures of pesticide application can slow the development of resistance, as can some natural features of the target population and surrounding environment.[4]

Alternatives

Alternatives to pesticides are available and include methods of cultivation, use of biological pest controls (such as pheromones and microbial pesticides), genetic engineering (mostly of crops), and methods of interfering with insect breeding.[21] Application of composted yard waste has also been used as a way of controlling pests.[96]

These methods are becoming increasingly popular and often are safer than traditional chemical pesticides. In addition, EPA is registering reduced-risk pesticides in increasing numbers.[citation needed]

Cultivation practices

Cultivation practices include polyculture (growing multiple types of plants), crop rotation, planting crops in areas where the pests that damage them do not live, timing planting according to when pests will be least problematic, and use of trap crops that attract pests away from the real crop.[21] Trap crops have successfully controlled pests in some commercial agricultural systems while reducing pesticide usage.[97] In other systems, trap crops can fail to reduce pest densities at a commercial scale, even when the trap crop works in controlled experiments.[98]

Use of other organisms

Release of other organisms that fight the pest is another example of an alternative to pesticide use. These organisms can include natural predators or parasites of the pests.[21] Biological pesticides based on entomopathogenic fungi, bacteria and viruses causing disease in the pest species can also be used.[21]

Biological control engineering

Interfering with insects' reproduction can be accomplished by sterilizing males of the target species and releasing them, so that they mate with females but do not produce offspring.[21] This technique was first used on the screwworm fly in 1958 and has since been used with the medfly, the tsetse fly,[99] and the gypsy moth.[100] This is a costly and slow approach that only works on some types of insects.[21]

Other alternatives

Other alternatives include "laserweeding" – the use of novel agricultural robots for weed control using lasers.[101]

Push pull strategy

The term "push-pull" was established in 1987 as an approach for integrated pest management (IPM). This strategy uses a mixture of behavior-modifying stimuli to manipulate the distribution and abundance of insects. "Push" means the insects are repelled or deterred away from whatever resource is being protected. "Pull" means that certain stimuli (semiochemical stimuli, pheromones, food additives, visual stimuli, genetically altered plants, etc.) are used to attract pests to trap crops where they will be killed.[102] There are numerous different components involved in order to implement a Push-Pull Strategy in IPM.

Many case studies testing the effectiveness of the push-pull approach have been done across the world. The most successful push-pull strategy was developed in Africa for subsistence farming. Another successful case study was performed on the control of Helicoverpa in cotton crops in Australia. In Europe, the Middle East, and the United States, push-pull strategies were successfully used in the controlling of Sitona lineatus in bean fields.[102]

Some advantages of using the push-pull method are less use of chemical or biological materials and better protection against insect habituation to this control method. Some disadvantages of the push-pull strategy are that if there is a lack of appropriate knowledge of the behavioral and chemical ecology of the host-pest interactions then this method becomes unreliable. Furthermore, because the push-pull method is not a very popular method of IPM operational and registration costs are higher.

Effectiveness

Some evidence shows that alternatives to pesticides can be equally effective as the use of chemicals. A study of Maize fields in northern Florida found that the application of composted yard waste with high carbon to nitrogen ratio to agricultural fields was highly effective at reducing the population of plant-parasitic nematodes and increasing crop yield, with yield increases ranging from 10% to 212%; the observed effects were long-term, often not appearing until the third season of the study.[96] Additional silicon nutrition protects some horticultural crops against fungal diseases almost completely, while insufficient silicon sometimes leads to severe infection even when fungicides are used.[103]

Pesticide resistance is increasing and that may make alternatives more attractive.

Types

Biopesticides

Main page: Biology:Biopesticide

Biopesticides are certain types of pesticides derived from such natural materials as animals, plants, bacteria, and certain minerals. For example, canola oil and baking soda have pesticidal applications and are considered biopesticides. Biopesticides fall into three major classes:

  • Microbial pesticides which consist of bacteria, entomopathogenic fungi or viruses (and sometimes includes the metabolites that bacteria or fungi produce). Entomopathogenic nematodes are also often classed as microbial pesticides, even though they are multi-cellular.[104][105]
  • Biochemical pesticides or herbal pesticides[106] are naturally occurring substances that control (or monitor in the case of pheromones) pests and microbial diseases.
  • Plant-incorporated protectants (PIPs) have genetic material from other species incorporated into their genetic material (i.e. GM crops). Their use is controversial, especially in many European countries.[107]

By pest type

Pesticides that are related to the type of pests are:[108]

Type Action
Algicides Control algae in lakes, canals, swimming pools, water tanks, and other sites
Avicides kill birds
Antifouling agents Kill or repel organisms that attach to underwater surfaces, such as boat bottoms
Antimicrobials Kill microorganisms (such as bacteria and viruses)
Attractants Attract pests (for example, to lure an insect or rodent to a trap).
Bactericides Kill bacteria
Biopesticides Certain types of pesticides derived from such natural materials as animals, plants, bacteria, and certain minerals
Biocides Kill microorganisms
Defoliants Cause leaves or foliage to drop from a plant, usually to facilitate harvest.
Desiccants Promote drying of living tissues, such as unwanted plant tops.
Disinfectants and sanitizers Kill or inactivate disease-producing microorganisms on inanimate objects
Fungicides Kill fungi (including blights, mildews, molds, and rusts)
Fumigants Produce gas or vapor intended to destroy pests in buildings or soil
Gene drives A genetic mechanism embedded into the genetic material of the target species, which can kill or suppress the reproductive of its descendants.[109]
Herbicides Kill weeds and other plants that grow where they are not wanted
Insect growth regulators Disrupt the molting, maturing from pupal stage to adult, or other life processes of insects.
Insecticides Kill insects and other arthropods
Lampricides Kills Lampreys
Miticides or acaricides Kill mites that feed on plants and animals
Microbial pesticides Microorganisms that kill, inhibit, or out compete pests, including insects or other microorganisms
Molluscicides Kill snails and slugs
Nematicides Kill nematodes (microscopic, worm-like organisms that feed on plant roots)
Ovicides Kill eggs of insects and mites
Pheromones Biochemicals used to disrupt the mating behavior of insects
Piscicide Kills fish
Plant growth regulators Alter the expected growth, flowering or reproduction rate of plants (does not include fertilizers).
Plant Incorporated protectants Substances that plants produce from genetic material that has been added to the plant.
Repellents Repel pests, including insects (such as mosquitoes) and birds
Rodenticides Control mice and other rodents
Slimicides Kill slime-producing microorganisms such as algae, bacteria, fungi, and slime molds
Soil sterilant Temporarily or permanently prevents the growth of all plants and animals[110]
Virucides Kills viruses.
Wood preservatives Used to make wood resistant to insects, fungi, and other pests.

Regulation

International

In many countries, pesticides must be approved for sale and use by a government agency.[111][112]

Worldwide, 85% of countries have pesticide legislation for the proper storage of pesticides and 51% include provisions to ensure proper disposal of all obsolete pesticides.[113]

Though pesticide regulations differ from country to country, pesticides, and products on which they were used are traded across international borders. To deal with inconsistencies in regulations among countries, delegates to a conference of the United Nations Food and Agriculture Organization adopted an International Code of Conduct on the Distribution and Use of Pesticides in 1985 to create voluntary standards of pesticide regulation for different countries.[111] The Code was updated in 1998 and 2002.[114] The FAO claims that the code has raised awareness about pesticide hazards and decreased the number of countries without restrictions on pesticide use.[6]

Three other efforts to improve regulation of international pesticide trade are the United Nations London Guidelines for the Exchange of Information on Chemicals in International Trade and the United Nations Codex Alimentarius Commission. The former seeks to implement procedures for ensuring that prior informed consent exists between countries buying and selling pesticides, while the latter seeks to create uniform standards for maximum levels of pesticide residues among participating countries.[115]

United States

Preparation for an application of hazardous herbicide in the US

In the United States , the Environmental Protection Agency (EPA) is responsible for regulating pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Food Quality Protection Act (FQPA).[116]

Studies must be conducted to establish the conditions in which the material is safe to use and the effectiveness against the intended pest(s).[117] The EPA regulates pesticides to ensure that these products do not pose adverse effects to humans or the environment, with an emphasis on the health and safety of children.[118] Pesticides produced before November 1984 continue to be reassessed in order to meet the current scientific and regulatory standards. All registered pesticides are reviewed every 15 years to ensure they meet the proper standards.[116] During the registration process, a label is created. The label contains directions for proper use of the material in addition to safety restrictions. Based on acute toxicity, pesticides are assigned to a Toxicity Class. Pesticides are the most thoroughly tested chemicals after drugs in the United States; those used on food require more than 100 tests to determine a range of potential impacts.[118]

Some pesticides are considered too hazardous for sale to the general public and are designated restricted use pesticides. Only certified applicators, who have passed an exam, may purchase or supervise the application of restricted use pesticides.[111] Records of sales and use are required to be maintained and may be audited by government agencies charged with the enforcement of pesticide regulations.[119][120] These records must be made available to employees and state or territorial environmental regulatory agencies.[121][122]

In addition to the EPA, the United States Department of Agriculture (USDA) and the United States Food and Drug Administration (FDA) set standards for the level of pesticide residue that is allowed on or in crops.[123] The EPA looks at what the potential human health and environmental effects might be associated with the use of the pesticide.[124]

In addition, the U.S. EPA uses the National Research Council's four-step process for human health risk assessment: (1) Hazard Identification, (2) Dose-Response Assessment, (3) Exposure Assessment, and (4) Risk Characterization.[125]

In 2013 Kaua'i County (Hawai'i) passed Bill No. 2491 to add an article to Chapter 22 of the county's code relating to pesticides and GMOs. The bill strengthens protections of local communities in Kaua'i where many large pesticide companies test their products.[126]

Canada

EU

EU legislation has been approved banning the use of highly toxic pesticides including those that are carcinogenic, mutagenic or toxic to reproduction, those that are endocrine-disrupting, and those that are persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB) and measures have been approved to improve the general safety of pesticides across all EU member states.[127]

In 2023 The Environment Committee of European Parliament approved a decision aiming to reduce pesticide use by 50% (the most hazardous by 65%) by the year 2030 and ensure sustainable use of pesticides (for example use them only as a last resort). The decision also includes measures for providing farmers with alternatives.[128]

Residue

Main page: Biology:Pesticide residue

Pesticide residue refers to the pesticides that may remain on or in food after they are applied to food crops.[129] The maximum residue limits (MRL) of pesticides in food are carefully set by the regulatory authorities to ensure, to their best judgement, no health impacts. Regulations such as pre-harvest intervals also often prevent harvest of crop or livestock products if recently treated in order to allow residue concentrations to decrease over time to safe levels before harvest. Exposure of the general population to these residues most commonly occurs through consumption of treated food sources, or being in close contact to areas treated with pesticides such as farms or lawns.[130]

Persistent pesticides are no longer used for agriculture, and will not be approved by the authorities.[131][132] Because the half life in soil is long (for DDT 2–15 years[133]) residues can still be detected in humans at levels 5 to 10 times lower than found in the 1970s.[134]

Residues are monitored by the authorities. In 2016, over 99% of samples of US produce had no pesticide residue or had residue levels well below the EPA tolerance levels for each pesticide.[135]

See also

References

  1. ↑ "Basic Information about Pesticide Ingredients" (in en). Environmental Protection Agency. April 2, 2018. https://www.epa.gov/ingredients-used-pesticide-products/basic-information-about-pesticide-ingredients. 
  2. ↑ "Pest Management". National Pesticide Applicator Certification Core Manual (2nd ed.). Washington: National Association of State Departments of Agriculture Research Foundation. 2014. https://www.nasda.org/foundation/pesticide-applicator-certification-and-training. Retrieved 2018-12-01. 
  3. ↑ "Pesticide Industry Sales and Usage, 2008 – 2012 Market Estimates". https://www.epa.gov/sites/default/files/2017-01/documents/pesticides-industry-sales-usage-2016_0.pdf. 
  4. ↑ 4.0 4.1 Dunlop, Erin S.; McLaughlin, Rob; Adams, Jean V.; Jones, Michael et al. (2018). "Rapid evolution meets invasive species control: the potential for pesticide resistance in sea lamprey". Canadian Journal of Fisheries and Aquatic Sciences (National Research Council Canada) 75 (1): 152–168. doi:10.1139/cjfas-2017-0015. ISSN 0706-652X. 
  5. ↑ Sykes, J. B. (1989). The Concise Oxford dictionary of current english (7th ed.). Oxford University Press. ISBN 978-0-19-861131-8. OCLC 848516593. 
  6. ↑ 6.0 6.1 "International Code of Conduct on the Distribution and Use of Pesticides". Food and Agriculture Organization of the United Nations. 2002. http://www.fao.org/WAICENT/FAOINFO/AGRICULT/AGP/AGPP/Pesticid/Code/Download/code.pdf. 
  7. ↑ "Types of pesticides". http://npic.orst.edu/ingred/ptype/index.html. 
  8. ↑ "Types of Pesticide Ingredients" (in en). Jan 3, 2017. https://www.epa.gov/ingredients-used-pesticide-products/types-pesticide-ingredients. 
  9. ↑ Zhang, Yu; Lorsbach, Beth A.; Castetter, Scott; Lambert, William T. et al. (2018). "Physicochemical property guidelines for modern agrochemicals". Pest Management Science 74 (9): 1979–1991. doi:10.1002/ps.5037. PMID 29667318. 
  10. ↑ Hofstetter, Sandro (2018). "How To Design for a Tailored Subcellular Distribution of Systemic Agrochemicals in Plant Tissues". J. Agric. Food Chem. 66 (33): 8687–8697. doi:10.1021/acs.jafc.8b02221. PMID 30024749. https://backend.orbit.dtu.dk/ws/files/167227061/Rev_Hofstetter_et_al_intracellular_localization_of_agrochemicals.pdf. 
  11. ↑ 11.0 11.1 11.2 "About Pesticide Registration". January 25, 2023. https://www.epa.gov/pesticide-registration/about-pesticide-registration#registration. 
  12. ↑ 12.0 12.1 12.2 "Approval of active substances". European Commission. https://food.ec.europa.eu/plants/pesticides/approval-active-substances_en. 
  13. ↑ 13.0 13.1 "WHO urges DDT for malaria control Strategies". Inter Press Service. September 16, 2006. http://www.commondreams.org/headlines06/0916-05.htm. 
  14. ↑ "Role of biopesticides in crop protection: present status and future prospects". Indian Journal of Plant Protection 35 (1): 1–9. 2007. http://oar.icrisat.org/872/1/Indian_Journal_of_Plant_Protection_35_1_1-9_2007.pdf. 
  15. ↑ 15.0 15.1 Miller, G. Tyler (2002). Living in the Environment (12th ed.). Belmont: Wadsworth/Thomson Learning. ISBN 9780534376970. OCLC 819417923. 
  16. ↑ 16.0 16.1 16.2 16.3 "Pinpointing Trends In Pesticide Use. Limited data indicate that pesticide use has dropped since the 1970s". Chemical & Engineering News (ACS) 87 (7). 2009. ISSN 0009-2347. https://cen.acs.org/articles/87/i7/Pinpointing-Trends-Pesticide-Use.html. 
  17. ↑ 17.0 17.1 17.2 "Managing pesticide chronic health risks: U.S. policies". Journal of Agromedicine 12 (1): 67–75. 2007. doi:10.1300/J096v12n02_08. PMID 18032337. 
  18. ↑ 18.0 18.1 "Chapter 14". Introduction to insect biology and diversity (2nd ed.). Oxford: Oxford University Press. 1998. pp. 279–300. ISBN 978-0195100334. OCLC 37211384. 
  19. ↑ Steen-Adams, Michelle (2002). "Russell, E. 2001. War and Nature: Fighting Humans and Insects with Chemicals from World War I to Silent Spring. Cambridge University Press, Cambridge, UK and New York, New York, USA.". Conservation Ecology 6 (2). doi:10.5751/es-00407-060201. ISSN 1195-5449. 
  20. ↑ "Pesticide Rotation". Ontario Ministry of Agriculture, Food and Rural Affairs. Dec 1, 2005. http://www.omafra.gov.on.ca/english/crops/hort/news/grower/2005/12gn05a2.htm. 
  21. ↑ 21.00 21.01 21.02 21.03 21.04 21.05 21.06 21.07 21.08 21.09 21.10 Miller, G. Tyler (2004). "Ch. 9. Biodiversity". Sustaining the Earth (6th ed.). Pacific Grove, CA: Thompson Learning, Inc.. pp. 211–216. ISBN 9780495556879. OCLC 52134759. 
  22. ↑ "Pesticide Usage in the United States: Trends During the 20th Century". Feb 2003. http://www.pestmanagement.info/pesticide_history/full_doc.pdf. 
  23. ↑ 23.0 23.1 Umetsu, Noriharu (May 2020). "Development of novel pesticides in the 21st century". Journal of Pesticide Science 45 (2): 54–74. doi:10.1584/jpestics.D20-201. PMID 33132734. 
  24. ↑ Sparks, Thomas C. (2021). "Crop protection compounds - trends and perspective". Pest Management Science 77 (8): 3608–3616. doi:10.1002/ps.6293. PMID 33486823. 
  25. ↑ Ling, Kenneth (2014). "Discovery of Agrochemicals". http://www.oxfordsynthesiscdt.ox.ac.uk/resources/SBM-CDT-Agrochemistry.pdf. 
  26. ↑ Bebber, Daniel P.; Gurr, Sarah J. (2015). "Crop-destroying fungal and oomycete pathogens challenge food security". Fungal Genetics and Biology (Academic Press) 74: 62–64. doi:10.1016/j.fgb.2014.10.012. ISSN 1087-1845. PMID 25459533. 
  27. ↑ Sparks, Thomas C. (2023). "Natural Product-Based Crop Protection Compounds─Origins and Future Prospects". Journal of Agricultural and Food Chemistry 71 (5): 2259–2269. doi:10.1021/acs.jafc.2c06938. PMID 36693160. 
  28. ↑ 28.0 28.1 Sparks, Thomas (May 2023). "Insecticide discovery–"Chance favors the prepared mind"". Pesticide Biochemistry and Physiology 192: 105412. doi:10.1016/j.pestbp.2023.105412. PMID 37105622. 
  29. ↑ 29.0 29.1 Ulrich, Elin M.; Morrison, Candice N.; Goldsmith, Michael R.; Foreman, William T. (2012). "Chiral Pesticides: Identification, Description, and Environmental Implications". Reviews of Environmental Contamination and Toxicology Volume 217. 217. Boston: Springer US. 1–74. doi:10.1007/978-1-4614-2329-4_1. ISBN 978-1-4614-2328-7.  (WTF RID: N-2573-2016).
  30. ↑ Bura, László (2019). "2019". ESFA Journal 17 (8): e05804. doi:10.2903/j.efsa.2019.5804. PMID 32626414. 
  31. ↑ "Interim Policy for Evaluation of Stereoisomeric Pesticides". 26 October 2000. https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/interim-policy-evaluation-stereoisomeric-pesticides. 
  32. ↑ Sparks, Thomas (August 2022). "Innovation in insecticide discovery: Approaches to the discovery of new classes of insecticides". Pest Management Science 78 (8): 3226–3247. doi:10.1002/ps.6942. PMID 35452182. 
  33. ↑ "Bees and pesticides: updated guidance for assessing risks". 11 May 2023. https://www.efsa.europa.eu/en/news/bees-and-pesticides-updated-guidance-assessing-risks. 
  34. ↑ Adriaanse, Pauline (11 May 2023). "Revised guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees)". EFSA Journal 21 (5): 7989. doi:10.2903/j.efsa.2023.7989. PMID 37179655. 
  35. ↑ "How We Assess Risks to Pollinators". 28 June 2023. https://www.epa.gov/pollinator-protection/how-we-assess-risks-pollinators. 
  36. ↑ "Managing Pesticide Risk to Insect Pollinators; Laws, Policies and Guidance". https://www.oecd.org/chemicalsafety/risk-mitigation-pollinators/laws-policies-guidance.htm. 
  37. ↑ 37.0 37.1 37.2 Whitford, F. (2009). The Benefits of Pesticides, A Story Worth Telling. Purdue Extension. https://www.extension.purdue.edu/extmedia/ppp/ppp-70.pdf. 
  38. ↑ 38.0 38.1 "Pesticides and aquatic animals: A guide to reducing impacts on aquatic systems". Jun 1996. http://www.ext.vt.edu/pubs/waterquality/420-013/420-013.html. 
  39. ↑ "The Lawn-Chemical Economy and Its Discontents". Antipode 35 (5): 955–979. 2003. doi:10.1111/j.1467-8330.2003.00366.x. Bibcode: 2003Antip..35..955R. 
  40. ↑ "WHO gives indoor use of DDT a clean bill of health for controlling malaria". Sep 15, 2006. https://www.who.int/mediacentre/news/releases/2006/pr50/en/. 
  41. ↑ "In Depth: DDT & Malaria". PAN Magazine. http://magazine.panna.org/summer2006/inDepthDDT.html. 
  42. ↑ "A Story to be Shared: the Successful Fight Against Malaria in Vietnam". WHO WPRO. Nov 6, 2000. http://www.afronets.org/files/malaria.pdf. 
  43. ↑ 43.0 43.1 "Pesticides use and trade 1990–2021". 2023. https://www.fao.org/3/cc6958en/cc6958en.pdf. 
  44. ↑ (in en) World Food and Agriculture – Statistical Yearbook 2023. Rome, Italy: Food and Agriculture Organization of the United Nations. 2023. doi:10.4060/cc8166en. ISBN 978-92-5-138262-2. https://www.fao.org/documents/card/en?details=cc8166en. Retrieved 2023-12-13. 
  45. ↑ "Pesticides Industry Sales and Usage 2008-2012". US EPA. 2012. https://www.epa.gov/sites/production/files/2017-01/documents/pesticides-industry-sales-usage-2016_0.pdf. 
  46. ↑ "U.S.: Number of households 1960-2017". https://www.statista.com/statistics/183635/number-of-households-in-the-us/. 
  47. ↑ 47.0 47.1 "Pesticide Illness & Injury Surveillance". NIOSH. Feb 7, 2017. https://www.cdc.gov/niosh/topics/pesticides/. 
  48. ↑ "Infographic: Pesticide Planet". Science 341 (6147): 730–1. August 2013. doi:10.1126/science.341.6147.730. PMID 23950524. Bibcode: 2013Sci...341..730.. 
  49. ↑ "Environmental Indicators of Pesticide Leaching and Runoff from Farm Fields". Agricultural Productivity. Studies in Productivity and Efficiency. 2. Boston: Springer. 2002. pp. 213–56. ISBN 978-1461352709. https://www.nrcs.usda.gov/Technical/land/pubs/eip_pap.html. 
  50. ↑ "Effects of Organic Fertilization and Pesticide Application on Growth and Yield of Field-Grown Rice for 10 Years" (in ja). Japanese Journal of Crop Science 70 (4): 530–540. 2001. doi:10.1626/jcs.70.530. 
  51. ↑ "Economic Impact of Reduced Pesticide Use in the United States: Measurement of Costs and Benefits". AFPC Policy Issues 99 (2). 1999. https://www.afpc.tamu.edu/research/publications/148/99-2.pdf. 
  52. ↑ 52.0 52.1 52.2 52.3 "The benefits of pesticides to mankind and the environment". Crop Protection 26 (9): 1337–1348. 2007. doi:10.1016/j.cropro.2007.03.022. https://croplifefoundation.org/Documents/Research%20Briefs/PesticideBenefitsResearchPaper.pdf. 
  53. ↑ "Roll Back Malaria: a failing global health campaign". BMJ 328 (7448): 1086–7. May 2004. doi:10.1136/bmj.328.7448.1086. PMID 15130956. 
  54. ↑ "Environmental and Economic Costs of Pesticide Use". BioScience 42 (10): 750–60. 1992. doi:10.2307/1311994. 
  55. ↑ "Health impact and damage cost assessment of pesticides in Europe". Environment International 49: 9–17. November 2012. doi:10.1016/j.envint.2012.08.001. PMID 22940502. 
  56. ↑ "National Assessment of the Worker Protection Workshop #3". U.S. Environmental Protection Agency. Aug 30, 2007. http://www.epa.gov/oppfead1/safety/newnote/workshop3.htm. 
  57. ↑ "Occupational exposure to chemicals and hearing impairment". https://www.norskoljeoggass.no/globalassets/dokumenter/drift/arbeidsmiljo/kjemisk-arbeidsmiljo/fagtema/horselsskadelige-kjemikalier/occupational-exposure-to-chemicals-and-hearing-impairment.pdf. 
  58. ↑ "Human Health Issues". US EPA. Jun 28, 2006. http://www.epa.gov/pesticides/health/human.htm. 
  59. ↑ "Cancer health effects of pesticides: systematic review". Canadian Family Physician 53 (10): 1704–11. October 2007. PMID 17934034. 
  60. ↑ 60.0 60.1 60.2 Jurewicz, Joanna; Hanke, Wojciech (2008). "Prenatal and Childhood Exposure to Pesticides and Neurobehavioral Development: Review of Epidemiological Studies". International Journal of Occupational Medicine and Environmental Health 21 (2): 121–32. doi:10.2478/v10001-008-0014-z. ISSN 1896-494X. PMID 18614459. http://oldwww.imp.lodz.pl/home_en/publishing_office/journals_/_ijomeh/&articleId=20947&l=PL. 
  61. ↑ "Pesticide exposures and developmental outcomes: the epidemiological evidence". Journal of Toxicology and Environmental Health Part B: Critical Reviews 10 (1–2): 41–80. 2007. doi:10.1080/10937400601034571. PMID 18074304. Bibcode: 2007JTEHB..10...41W. 
  62. ↑ "Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants". Journal of Toxicology and Environmental Health Part B: Critical Reviews 11 (5–6): 373–517. May 2008. doi:10.1080/10937400801921320. PMID 18470797. Bibcode: 2008JTEHB..11..373W. 
  63. ↑ "Epidemiologic studies of glyphosate and non-cancer health outcomes: a review". Regulatory Toxicology and Pharmacology 61 (2): 172–84. November 2011. doi:10.1016/j.yrtph.2011.07.006. PMID 21798302. 
  64. ↑ "Non-cancer health effects of pesticides: systematic review and implications for family doctors". Canadian Family Physician 53 (10): 1712–20. October 2007. PMID 17934035. 
  65. ↑ Roberts, James R.; Karr, Catherine J. (December 2012). "Pesticide exposure in children". Pediatrics 130 (6): e1757–63. doi:10.1542/peds.2012-2757. PMID 23184103. 
  66. ↑ 66.0 66.1 Goldmann, Lynn (May 2004). Childhood Pesticide Poisoning: Information for Advocacy and Action (Report). WHO. https://www.who.int/ceh/publications/pestpoisoning.pdf. 
  67. ↑ "The global distribution of fatal pesticide self-poisoning: systematic review". BMC Public Health 7 (1): 357. December 2007. doi:10.1186/1471-2458-7-357. PMID 18154668. 
  68. ↑ "Environmental chemical exposures and autism spectrum disorders: a review of the epidemiological evidence". Current Problems in Pediatric and Adolescent Health Care 44 (10): 277–318. November 2014. doi:10.1016/j.cppeds.2014.06.001. PMID 25199954. 
  69. ↑ "Acute pesticide poisoning: a major global health problem". World Health Statistics Quarterly. Rapport Trimestriel de Statistiques Sanitaires Mondiales 43 (3): 139–44. 1990. PMID 2238694. 
  70. ↑ "Children's Health in Latin America: The Influence of Environmental Exposures". Environmental Health Perspectives 123 (3): 201–209. 2015. doi:10.1289/ehp.1408292. ISSN 0091-6765. PMID 25499717. 
  71. ↑ "Agriculture & Food Security". https://www.eac.int/agriculture#:~:text=The%20major%20food%20crops%20are,tobacco,%20coconut%20and%20cashew%20nuts.. 
  72. ↑ 72.0 72.1 Mekonnen, Yalemtsehay; Ejigu, D. (September 2005). "Plasma cholinesterase level of Ethiopian farm workers exposed to chemical pesticide". Occupational Medicine (Oxford, England) 55 (6): 504–505. doi:10.1093/occmed/kqi088. ISSN 0962-7480. PMID 16140842. 
  73. ↑ 73.0 73.1 73.2 "Self reported symptoms and inhibition of acetylcholinesterase activity among Kenyan agricultural workers". Occupational and Environmental Medicine 57 (3): 195–200. 2000. doi:10.1136/oem.57.3.195. ISSN 1351-0711. PMID 10810102. 
  74. ↑ 74.0 74.1 Magauzi, Regis; Mabaera, Bigboy; Rusakaniko, Simbarashe; Chimusoro, Anderson et al. (2011-07-11). "Health effects of agrochemicals among farm workers in commercial farms of Kwekwe district, Zimbabwe". The Pan African Medical Journal 9 (1): 26. doi:10.4314/pamj.v9i1.71201. ISSN 1937-8688. PMID 22145061. 
  75. ↑ Mekonnen, Yalemtsehay; Agonafir, Tadesse (2004). "Lung function and respiratory symptoms of pesticide sprayers in state farms of Ethiopia". Ethiopian Medical Journal 42 (4): 261–266. ISSN 0014-1755. PMID 16122117. 
  76. ↑ 76.0 76.1 76.2 76.3 76.4 "Biological monitoring of exposure to pesticides: current issues". Toxicology Letters 108 (2–3): 277–283. 1999-09-05. doi:10.1016/S0378-4274(99)00099-5. PMID 10511272. 
  77. ↑ ((World Health Organization. Office of Occupational Health.)) (1996) (in en). Biological monitoring of chemical exposure in the workplace: guidelines. World Health Organization. ISBN 978-951-802-158-5. https://apps.who.int/iris/handle/10665/41856. 
  78. ↑ Wesseling, Catharina; De Joode, Berna Van Wendel; Ruepert, Clemens; León, Catalina et al. (October 2001). "Paraquat in Developing Countries" (in en). International Journal of Occupational and Environmental Health 7 (4): 275–286. doi:10.1179/oeh.2001.7.4.275. ISSN 1077-3525. PMID 11783857. http://www.maneyonline.com/doi/abs/10.1179/oeh.2001.7.4.275. 
  79. ↑ 79.0 79.1 Tosi, Simone; Costa, Cecilia; Vesco, Umberto; Quaglia, Giancarlo; Guido, Giovanni (2018). "A survey of honey bee-collected pollen reveals widespread contamination by agricultural pesticides". Science of the Total Environment 615: 208–218. doi:10.1016/j.scitotenv.2017.09.226. PMID 28968582. 
  80. ↑ "Soyalism | DW Documentary". Brazil. February 21, 2020. https://www.youtube.com/watch?v=ksrc7eI3IMY&t=1459. 
  81. ↑ Dicks, Lynn V.; Breeze, Tom D.; Ngo, Hien T.; Senapathi, Deepa et al. (16 August 2021). "A global-scale expert assessment of drivers and risks associated with pollinator decline". Nature Ecology & Evolution 5 (10): 1453–1461. doi:10.1038/s41559-021-01534-9. PMID 34400826. Bibcode: 2021NatEE...5.1453D. http://rid.unrn.edu.ar/handle/20.500.12049/7526. 
  82. ↑ Goulson, Dave; Nicholls, Elizabeth; Botías, Cristina; Rotheray, Ellen L. (27 March 2015). "Bee declines driven by combined stress from parasites, pesticides, and lack of flowers". Science 347 (6229): 1255957. doi:10.1126/science.1255957. PMID 25721506. 
  83. ↑ Wells, Matt (March 11, 2007). "Vanishing bees threaten U.S. crops". London. http://news.bbc.co.uk/2/hi/americas/6438373.stm. 
  84. ↑ "Wildlife & Pesticides - Peanuts". North Carolina Cooperative Extension Service. http://ipm.ncsu.edu/wildlife/peanuts_wildlife.html. 
  85. ↑ "Pesticides and health risks". Journal of Obstetric, Gynecologic, and Neonatal Nursing 39 (1): 103–10. January 2010. doi:10.1111/j.1552-6909.2009.01092.x. PMID 20409108. 
  86. ↑ "Ridding The World of Pops: A Guide to the Stockholm Convention on Persistent Organic Pollutants". United Nations Environment Programme. April 2005. http://www.pops.int/documents/guidance/beg_guide.pdf. 
  87. ↑ Castro, Peter; Huber, Michael E. (2010). Marine Biology (8th ed.). New York: McGraw-Hill Companies Inc.. ISBN 9780073524160. OCLC 488863548. 
  88. ↑ Pesticide Usage in the United States: History, Benefits, Risks, and Trends; Bulletin 1121, November 2000, K.S. Delaplane, Cooperative Extension Service, The University of Georgia College of Agricultural and Environmental Sciences "Archived copy". http://pubs.caes.uga.edu/caespubs/pubs/PDF/B1121.pdf. 
  89. ↑ Quinn, Amie L. (2007). The impacts of agricultural chemicals and temperature on the physiological stress response in fish (MSc Thesis). Lethbridge: University of Lethbridge.
  90. ↑ "National Biomonitoring Program". April 7, 2017. https://www.cdc.gov/biomonitoring/DDT_BiomonitoringSummary.html. 
  91. ↑ "Dichlorodiphenyltrichloroethane (DDT) Factsheet". August 16, 2021. https://www.cdc.gov/biomonitoring/DDT_FactSheet.html. 
  92. ↑ "Factors controlling degradation of pesticides in soil". Pesticide Science 55 (5): 598–601. 1999. doi:10.1002/(SICI)1096-9063(199905)55:5<598::AID-PS962>3.0.CO;2-N. ISSN 1096-9063. 
  93. ↑ "Biodegradation of pyridine derivatives in soil suspensions". Environmental Toxicology and Chemistry 5 (6): 503–509. 1986. doi:10.1897/1552-8618(1986)5[503:bopdis2.0.co;2]. 
  94. ↑ "Products and kinetics of cloramsulam-methyl aerobic soil metabolism". J. Agric. Food Chem. 44: 324–332. 1996. doi:10.1021/jf9503570. 
  95. ↑ 95.0 95.1 95.2 "Environmental and Economic Costs of the Application of Pesticides Primarily in the United States". Environment, Development and Sustainability 7 (2): 229–252. 2005. doi:10.1007/s10668-005-7314-2. http://www.beyondpesticides.org/documents/pimentel.pesticides.2005update.pdf. 
  96. ↑ 96.0 96.1 "Effect of yard waste compost on nematode densities and maize yield". Journal of Nematology 28 (4S): 655–60. December 1996. PMID 19277191. 
  97. ↑ "Concepts and applications of trap cropping in pest management". Annual Review of Entomology 51 (1): 285–308. Dec 6, 2005. doi:10.1146/annurev.ento.51.110104.150959. PMID 16332213. 
  98. ↑ Holden, Matthew H.; Ellner, Stephen P.; Lee, Doo-Hyung; Nyrop, Jan P.; Sanderson, John P. (2012-06-01). "Designing an effective trap cropping strategy: the effects of attraction, retention and plant spatial distribution". Journal of Applied Ecology 49 (3): 715–722. doi:10.1111/j.1365-2664.2012.02137.x. Bibcode: 2012JApEc..49..715H. 
  99. ↑ "The Biological Control of Pests". Jul 25, 2007. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/B/Biocontrols.html. 
  100. ↑ Summerlin, Lee B., ed (1977). "Chapter 17: Life Sciences". Skylab, Classroom in Space. Washington: MSFC. https://history.nasa.gov/SP-401/ch17.htm. Retrieved Sep 17, 2007. 
  101. ↑ Papadopoulos, Loukia (21 October 2022). "This new farming robot uses lasers to kill 200,000 weeds per hour". interestingengineering.com. https://interestingengineering.com/innovation/farming-robot-lasers-200000-weeds-per-hour. 
  102. ↑ 102.0 102.1 "The use of push-pull strategies in integrated pest management". Annual Review of Entomology 52 (1): 375–400. 2007. doi:10.1146/annurev.ento.52.110405.091407. PMID 16968206. 
  103. ↑ Epstein, Emanuel (1999). "Silicon". Annual Review of Plant Physiology and Plant Molecular Biology (Annual Reviews) 50 (1): 641–664. doi:10.1146/annurev.arplant.50.1.641. ISSN 1040-2519. PMID 15012222. 
  104. ↑ Coombs, Amy (Jan 1, 2013). "Fighting Microbes with Microbes". The Scientist. http://www.the-scientist.com/?articles.view/articleNo/33703/title/Fighting-Microbes-with-Microbes/. 
  105. ↑ Borgio, J. Francis, ed (2011). Microbial Insecticides: Principles and Applications. New York: Nova Science Publishers. pp. 492. ISBN 9781619427709. OCLC 780442651. 
  106. ↑ "Antifungal activity of some common weed extracts against wilt causing fungi, Fusarium oxysporum". Current Discovery 2 (1): 62–67. 2013. ISSN 2320-4400. https://www.academia.edu/5848539. 
  107. ↑ "Plant Incorporated Protectants (PIPs) / Genetically Modified Plants". US NPIC. February 9, 2017. http://npic.orst.edu/reg/pip.html. 
  108. ↑ "Types of Pesticides". US EPA. http://www.epa.gov/pesticides/about/types.htm. 
  109. ↑ Dhole, Sumit; Lloyd, Alun L.; Gould, Fred (2020-11-02). "Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex". Annual Review of Ecology, Evolution, and Systematics (Annual Reviews) 51 (1): 505–531. doi:10.1146/annurev-ecolsys-031120-101013. ISSN 1543-592X. PMID 34366722. 
  110. ↑  This article incorporates public domain material from the Congressional Research Service document "Report for Congress: Agriculture: A Glossary of Terms, Programs, and Laws, 2005 Edition" by Jasper Womach.
  111. ↑ 111.0 111.1 111.2 Willson, Harold R. (1996). "Pesticide Regulations". in Radcliffe, E. B.. Radcliffe's IPM World Textbook. St. Paul: University of Minnesota. https://ipmworld.umn.edu/wilson-regulations. 
  112. ↑ "Laws of Malaysia. Act 149: Pesticides Act 1974". Jun 1, 2015. http://pest-aside.com.my/Act_149-Pesticides_Act_1974_Malaysia_Kota_Kinabalu.pdf. 
  113. ↑ Food and Agriculture Organization of the United Nations; World Health Organization (14 November 2019). Global situation of pesticide management in agriculture and public health: Report of a 2018 WHO–FAO survey. Food & Agriculture Org.. pp. 25–. ISBN 978-92-5-131969-7. https://books.google.com/books?id=tGe_DwAAQBAJ&pg=PA25. 
  114. ↑ "Programmes: International Code of Conduct on the Distribution and Use of Pesticides". UN FAO. http://www.fao.org/ag/AGP/AGPP/Pesticid/Code/PM_Code.htm. 
  115. ↑ "International Pesticide Trade: Is There any Hope for the Effective Regulation of Controlled Substances?". Journal of Land Use & Environmental Law 13 (1): 69–105. 1997. http://www.law.fsu.edu/journals/landuse/vol131/reyn.html. 
  116. ↑ 116.0 116.1 "Pesticides and Public Health". US EPA. 2015-08-20. http://www.epa.gov/pesticides/health/public.htm#regulation. 
  117. ↑ "Data Requirements for Pesticide Registration". US EPA. 2015-08-20. http://www.epa.gov/pesticides/regulating/data_requirements.htm. 
  118. ↑ 118.0 118.1 Wayland, Susan; Fenner-Crisp, Penelope (April 2020). "Reducing Pesticide Risks: A Half Century of Progress". EPA Alumni Association. http://www.epaalumni.org/hcp/pesticides.pdf. 
  119. ↑ "Protocol for Conducting Environmental Compliance Audits under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)". US EPA. 2011. http://www.epa.gov/compliance/resources/policies/incentives/auditing/apcol-fifra.pdf. 
  120. ↑ "Ch. 11. Restricted-Use Pesticides: Dealer and Applicator Records Inspections". Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Inspection Manual. Washington: US EPA. 2013. pp. 11–1–11–4. https://www.epa.gov/sites/production/files/2014-01/documents/fiframanual.pdf. 
  121. ↑ "Chemical Hazard Communication". United States Department of Labor; OSHA. 1998. https://www.osha.gov/Publications/osha3084.html. 
  122. ↑ "Emergency Planning and Community Right-to-Know Act (EPCRA)". US EPA. Jul 24, 2013. https://www.epa.gov/epcra. 
  123. ↑ Toth, Stephen J. Jr. (Mar 1996). "Federal Pesticide Laws and Regulations". North Carolina Cooperative Extension Service. http://ipm.ncsu.edu/safety/factsheets/laws.pdf. 
  124. ↑ "Pesticide Registration Program". US EPA. 2010. http://www.epa.gov/pesticides/factsheets/registration.htm. 
  125. ↑ "Assessing Health Risks from Pesticides". US EPA. Apr 5, 2007. http://www.epa.gov/pesticides/factsheets/riskassess.htm. 
  126. ↑ "Bill No. 2491, Draft 2". Council of the County of Kaua'i. October 17, 2013. http://media.wix.com/ugd/5f73cf_56e4e700de9ae57e7b709740824bbed4.pdf. 
  127. ↑ "MEPs approve pesticides legislation". EU Parliament. Jan 13, 2009. http://www.europarl.europa.eu/news/expert/infopress_page/066-45937-012-01-03-911-20090112IPR45936-12-01-2009-2009-false/default_en.htm. 
  128. ↑ Hemingway Jaynes, Cristen (25 October 2023). "EU Votes to Cut Pesticide Use in Half by 2030". https://www.ecowatch.com/eu-pesticide-reduction-2030.html. 
  129. ↑ McNaught, Alan D., ed (1987). "Pesticide Residue". Compendium of Chemical Terminology (2nd ed.). Oxford: Blackwell. doi:10.1351/goldbook.P04520. ISBN 978-0-9678550-9-7. OCLC 901451465.  XML on-line corrected version created by Nic M, Jirat J, Kosata B; updates compiled by Jenkins A.
  130. ↑ "Pesticide Residues in Food". US EPA. Dec 5, 2011. http://cfpub.epa.gov/eroe/index.cfm?fuseaction=detail.viewInd&lv=list.listByAlpha&r=224028&subtop=312. 
  131. ↑ "About Pesticide Registration". January 4, 2024. https://www.epa.gov/pesticide-registration/about-pesticide-registration#registration. 
  132. ↑ "Approval of pesticides and herbicides in the EU". European Commission. https://food.ec.europa.eu/plants/pesticides/approval-active-substances_en. 
  133. ↑ "National Biomonitoring Program". April 7, 2017. https://www.cdc.gov/biomonitoring/DDT_BiomonitoringSummary.html. 
  134. ↑ "Dichlorodiphenyltrichloroethane (DDT) Factsheet". August 16, 2021. https://www.cdc.gov/biomonitoring/DDT_FactSheet.html. 
  135. ↑ "Pesticide Data Program". https://www.ams.usda.gov/datasets/pdp. 

Bibliography

  • Davis, Frederick Rowe. "Pesticides and the perils of synecdoche in the history of science and environmental history." History of Science 57.4 (2019): 469–492.
  • Davis, Frederick Rowe. Banned: a history of pesticides and the science of toxicology (Yale UP, 2014).
  • Matthews, Graham A. A history of pesticides (CABI, 2018).
  • S.Safe; H.Plugge; J.F.S.Crocker (1977). "Analysis of an aromatic solvent used in a forest spray program". Chemosphere 6 (10): 641–651. doi:10.1016/0045-6535(77)90075-3. Bibcode: 1977Chmsp...6..641S. 

Sources

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