Chemistry:TBPO

From HandWiki
TBPO[1]
TBPO.svg
Names
Preferred IUPAC name
4-tert-Butyl-2,6,7-trioxa-1λ5-phosphabicyclo[2.2.2]octan-1-one
Other names
t-Butyl-bicyclophosphate
Identifiers
3D model (JSmol)
ChemSpider
Properties
C8H15O4P
Molar mass 206.178 g·mol−1
Hazards
Main hazards Extremely toxic
Lethal dose or concentration (LD, LC):
36 μg/kg (mice)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

TBPO is an extremely toxic bicyclic phosphate convulsant and GABA receptor antagonist. It is the most toxic bicyclic phosphate known, with an -1">50 of 36 μg/kg in mice.[2]

See also

References

  1. ↑ Zhao, C.; Hwang, S. H.; Buchholz, B. A.; Carpenter, T. S.; Lightstone, F. C.; Yang, J.; Hammock, B. D.; Casida, J. E. (27 May 2014). "GABAA receptor target of tetramethylenedisulfotetramine". Proceedings of the National Academy of Sciences 111 (23): 8607–8612. doi:10.1073/pnas.1407379111. PMID 24912155. Bibcode: 2014PNAS..111.8607Z. 
  2. ↑ Milbrath, Dean S.; Engel, Judith L.; Verkade, John G.; Casida, John E. (February 1979). "Structure-toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes". Toxicology and Applied Pharmacology 47 (2): 287–293. doi:10.1016/0041-008x(79)90323-5. PMID 452023. 

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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

}}



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