Chemistry:Bicyclic phosphate

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Short description: Class of chemical compounds

Bicyclic phosphate is a class of organophosphate compounds that are used as flame retardants, stabilizers and antioxidants. They are also used in spectroscopic studies.[1][2]

Some bicyclic phosphates, such as TBPS, TBPO and IPTBO, are highly toxic. They have toxicity comparable to nerve agents. However, they are not acetylcholinesterase inhibitors.[1] They act as GABA receptor antagonists and have potent convulsant effects.[2][3][4]

See also

References

  1. ↑ 1.0 1.1 Bellet, E. M.; Casida, J. E. (14 December 1973). "Bicyclic Phosphorus Esters: High Toxicity without Cholinesterase Inhibition". Science 182 (4117): 1135–1136. doi:10.1126/science.182.4117.1135. PMID 4356280. Bibcode: 1973Sci...182.1135B. 
  2. ↑ 2.0 2.1 Gupta, Ramesh C., ed (2009). Handbook of toxicology of chemical warfare agents (1st ed.). London: Academic Press. ISBN 9780123744845. 
  3. ↑ BOWERY, N. G.; COLLINS, J. F.; HILL, R. G. (17 June 1976). "Bicyclic phosphorus esters that are potent convulsants and GABA antagonists". Nature 261 (5561): 601–603. doi:10.1038/261601a0. PMID 934303. Bibcode: 1976Natur.261..601B. 
  4. ↑ Ellison, D. Hank (2007). Handbook of chemical and biological warfare agents (2nd ed.). Boca Raton, Fla.: CRC. ISBN 9780849314346. 

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