Biology:RAB3A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene.[1][2][3] It is involved in calcium-triggered exocytosis in neurons.
Interactions
RAB3A has been shown to interact with:
References
- ↑ "Chromosome mapping of the human ras-related rab3A gene to 19p13.2". Genomics 5 (4): 694–8. January 1990. doi:10.1016/0888-7543(89)90110-9. PMID 2687157.
- ↑ "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol Cell Biol 15 (3): 1137–43. March 1995. doi:10.1128/MCB.15.3.1137. PMID 7532276.
- ↑ "Entrez Gene: RAB3A RAB3A, member RAS oncogene family". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5864.
- ↑ 4.0 4.1 "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. April 2003. doi:10.1074/jbc.M212341200. PMID 12578829.
- ↑ "Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming". Neuron 30 (1): 183–96. April 2001. doi:10.1016/s0896-6273(01)00272-0. PMID 11343654.
- ↑ "Protein unc-13 homolog A". https://www.uniprot.org/uniprot/Q9UPW8.
- ↑ "Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A". Cell 96 (3): 363–74. February 1999. doi:10.1016/S0092-8674(00)80549-8. PMID 10025402.
- ↑ "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". J. Biol. Chem. 271 (12): 6963–71. March 1996. doi:10.1074/jbc.271.12.6963. PMID 8636125.
- ↑ "REP-2, a Rab escort protein encoded by the choroideremia-like gene". J. Biol. Chem. 269 (3): 2111–7. January 1994. doi:10.1016/S0021-9258(17)42142-9. PMID 8294464.
- ↑ "Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface". Biochem. Biophys. Res. Commun. 301 (1): 92–7. January 2003. doi:10.1016/s0006-291x(02)02963-7. PMID 12535645.
Further reading
- "Isoprenoid modification of rab proteins terminating in CC or CXC motifs.". Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6264–8. 1991. doi:10.1073/pnas.88.14.6264. PMID 1648736. Bibcode: 1991PNAS...88.6264K.
- "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.". J. Biol. Chem. 264 (21): 12394–401. 1989. doi:10.1016/S0021-9258(18)63872-4. PMID 2501306.
- "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 11963–7. 1995. doi:10.1073/pnas.91.25.11963. PMID 7991565.
- "The Rab3A GTPase interacts with multiple factors through the same effector domain. Mutational analysis of cross-linking of Rab3A to a putative target protein.". J. Biol. Chem. 268 (32): 24449–52. 1993. doi:10.1016/S0021-9258(20)80546-8. PMID 8226995.
- "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. 1993. doi:10.1006/geno.1993.1021. PMID 8432525. https://zenodo.org/record/1229582.
- "Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II.". Eur. J. Biochem. 239 (2): 362–8. 1996. doi:10.1111/j.1432-1033.1996.0362u.x. PMID 8706741.
- "An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4.". J. Biol. Chem. 272 (6): 3663–8. 1997. doi:10.1074/jbc.272.6.3663. PMID 9013620.
- "The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion.". Nature 387 (6635): 810–4. 1997. doi:10.1038/42954. PMID 9194562.
- "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor.". J. Biol. Chem. 272 (43): 26991–8. 1997. doi:10.1074/jbc.272.43.26991. PMID 9341137.
- "Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A.". Cell 96 (3): 363–74. 1999. doi:10.1016/S0092-8674(00)80549-8. PMID 10025402.
- "Phosphatidic acid is important to the translocation of Rab3A from the cytosol to phospholipid membranes.". NeuroReport 10 (13): 2859–63. 1999. doi:10.1097/00001756-199909090-00029. PMID 10511453.
- "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.". Cell. Signal. 11 (10): 735–42. 2000. doi:10.1016/S0898-6568(99)00037-6. PMID 10574328.
- "Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP.". J. Biol. Chem. 275 (41): 31786–91. 2000. doi:10.1074/jbc.M003705200. PMID 10859313.
- "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells.". J. Biol. Chem. 276 (13): 9726–32. 2001. doi:10.1074/jbc.M006959200. PMID 11134008.
- "The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins.". FEBS Lett. 497 (2–3): 99–102. 2001. doi:10.1016/S0014-5793(01)02450-4. PMID 11377421.
- "GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.". Neuron 31 (3): 439–51. 2001. doi:10.1016/S0896-6273(01)00384-1. PMID 11516400.
- "Subcellular distribution and function of Rab3A-D in pancreatic acinar AR42J cells.". Biochem. Biophys. Res. Commun. 287 (3): 746–51. 2001. doi:10.1006/bbrc.2001.5651. PMID 11563859.
- "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.". J. Biol. Chem. 277 (11): 9212–8. 2002. doi:10.1074/jbc.M112414200. PMID 11773082.
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