Chemistry:Hyzetimibe
From HandWiki
Hyzetimibe is a pharmaceutical drug that inhibits cholesterol absorption.[1][2] It targets the NPC1-like intracellular cholesterol transporter 1.[2]
It reduces plasma levels of low-density lipoprotein cholesterol (LDL-C) by blocking the Niemann-Pick C1-like 1 protein, a transporter mainly found in the intestine that allows dietary cholesterol to enter the body from the intestinal lumen.[3]
In China, it is used as a lipid-lowering agent and it has efficacy similar to ezetimibe.[4]
References
- ↑ "Pharmacokinetics, pharmacodynamics, safety, and tolerability of hyzetimibe (HS-25) in healthy Chinese subjects". Journal of Clinical Pharmacology 54 (10): 1144–1152. October 2014. doi:10.1002/jcph.310. PMID 24752831.
- ↑ 2.0 2.1 "The NPC1L1 Gene Exerts a Notable Impact on the Reduction of Low-Density Lipoprotein Cholesterol in Response to Hyzetimibe: A Factorial-Designed Clinical Trial". Frontiers in Pharmacology 13. 2022. doi:10.3389/fphar.2022.755469. PMID 35359877.
- ↑ Pharmacokinetic Study of Oral 14C-Radiolabeled Hyzetimibe, A New Cholesterol Absorption Inhibitor
- ↑ "2023 Chinese guideline for lipid management". Frontiers in Pharmacology 14. 2023. doi:10.3389/fphar.2023.1190934. PMID 37711173.
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