Chemistry:Clinofibrate
From HandWiki
Clinofibrate (INN; trade name Lipoclin) is pharmaceutical drug of the fibrate class that is used for managing hyperlipidemia and associated conditions.[1] It is sold and marketed in Japan.[2]
Chemically, it is a derivative of bisphenol Z.[3]
Synthesis
The condensation between cyclohexanone (1) and phenol (2) gives bisphenol Z (3).[4] This is treated with chloroform and methyl ethyl ketone (MEK) in the presence of base. The resulting Bargellini reaction gives clinofibrate (4).[5]
Synthesis of clinofibrate
References
- ↑ "What is Clinofibrate used for?". Synapse. 14 June 2024. https://synapse.patsnap.com/article/what-is-clinofibrate-used-for.
- ↑ "Clinofibrate". DrugBank. https://go.drugbank.com/drugs/DB09006.
- ↑ "Effect of clinofibrate, a new hypolipidemic agent, on biliary and serum lipids in patients with hyperlipidemia". Atherosclerosis 42 (2–3): 129–39. April 1982. doi:10.1016/0021-9150(82)90145-9. PMID 7073798.
- ↑ "An Improved, Highly Efficient Method for the Synthesis of Bisphenols". e-Journal of Chemistry 8 (4): 2016–2019. 2011. doi:10.1155/2011/372673.
- ↑ Nakamura Y, Aono S, Agatsuma K, Tanaka Y, "Phenoxy carboxylic acid derivative", US patent 3716583, issued 13 February 1973
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