Chemistry:Simfibrate

Short description: Chemical compound

Simfibrate

Clinical data
Trade names	Cholesolvin
Other names	3-{[2-(4-Chlorophenoxy)-2-methylpropanoyl]oxy}propyl 2-(4-chlorophenoxy)-2-methylpropanoate
ATC code	C10AB06 (WHO)
Identifiers
IUPAC name Propane-1,3-diyl bis[2-(4-chlorophenoxy)-2-methylpropanoate]
CAS Number	14929-11-4
PubChem CID	5217
ChemSpider	5028 Y
UNII	L2R75RQX26
KEGG	D01212 Y
Chemical and physical data
Formula	C23H26Cl2O6
Molar mass	469.36 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc2ccc(OC(C(=O)OCCCOC(=O)C(Oc1ccc(Cl)cc1)(C)C)(C)C)cc2
InChI InChI=1S/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3 Y Key:JLRNKCZRCMIVKA-UHFFFAOYSA-N Y
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Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia. The substance is a double ester of clofibric acid with 1,3-propanediol which is cleaved in the body to one molecule of 1,3-propanediol and two molecules of clofibric acid which is the true lipid-lowering agent.