Medicine:Cardiotoxicity

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Short description: Poisoning of heart electrophysiology or muscle

Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity.[1] The heart becomes weaker and is not as efficient in pumping blood. Cardiotoxicity may be caused by chemotherapy (a usual example is the class of anthracyclines)[2][3] treatment and/or radiotherapy;[4] complications from anorexia nervosa; adverse effects of heavy metals intake;[5] the long-term abuse of or ingestion at high doses of certain strong stimulants such as cocaine;[6] or an incorrectly administered drug such as bupivacaine.[7]

One of the ways to detect cardiotoxicity at early stages when there is a subclinical dysfunction is by measuring changes in regional function of the heart using strains.[citation needed]

See also

References

  1. ↑ Sishi, Balindiwe J. N. (2015-01-01), Hayat, M. A., ed., "Chapter 10 - Autophagy Upregulation Reduces Doxorubicin-Induced Cardiotoxicity" (in en), Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (Amsterdam: Academic Press): pp. 157–173, doi:10.1016/b978-0-12-801033-4.00010-2, ISBN 978-0-12-801033-4, https://www.sciencedirect.com/science/article/pii/B9780128010334000102, retrieved 2022-07-06 
  2. ↑ Huang, C.; Zhang, X.; Ramil, J. M.; Rikka, S.; Kim, L.; Lee, Y.; Gude, N. A.; Thistlethwaite, P. A. et al. (2010). "Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice. Cardiotoxins are the second most toxic venom while neurotoxins are the first.". Circulation 121 (5): 675–83. doi:10.1161/CIRCULATIONAHA.109.902221. PMID 20100968. 
  3. ↑ "Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment". Curr Cardiol Rev 7 (4): 214–220. 2011. doi:10.2174/157340311799960645. PMID 22758622. 
  4. ↑ Suchorska, Wiktoria M. (2020-01-01). "Radiobiological models in prediction of radiation cardiotoxicity" (in en). Reports of Practical Oncology & Radiotherapy 25 (1): 46–49. doi:10.1016/j.rpor.2019.12.001. ISSN 1507-1367. PMID 31889920. 
  5. ↑ Nigra, Anne E; Ruiz-Hernandez, Adrian; Redon, Josep; Navas-Acien, Ana; Tellez-Plaza, Maria (2016). "Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review beyond Lead and Cadmium". Current Environmental Health Reports 3 (4): 416–433. doi:10.1007/s40572-016-0117-9. ISSN 2196-5412. PMID 27783356. 
  6. ↑ Pergolizzi, Joseph V; Magnusson, Peter; LeQuang, Jo Ann K; Breve, Frank; Varrassi, Giustino (2021). "Cocaine and Cardiotoxicity: A Literature Review". Cureus 13 (4): e14594. doi:10.7759/cureus.14594. ISSN 2168-8184. PMID 34036012. 
  7. ↑ "[Cardiotoxicity of local anesthetics]". Cahiers d'Anesthésiologie 41 (6): 589–598. 1993. PMID 8287299. 




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