Chemistry:Pemirolast
 | |
| Clinical data | |
|---|---|
| Trade names | Alamast |
| AHFS/Drugs.com | Monograph |
| Pregnancy category |
|
| Routes of administration | Oral, ophthalmic |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C10H8N6O |
| Molar mass | 228.215 g·mol−1 |
| 3D model (JSmol) | |
| |
  (what is this?) (verify) | |
Pemirolast (INN) is a mast cell stabilizer used as an anti-allergic drug therapy. It is marketed under the tradenames Alegysal and Alamast.
Clinical trials studying treatments for allergic conjunctivitis have found that an ophthalmic solution containing levocabastine with pemirolast potassium may be more effective in alleviating symptoms than levocabastine alone.[2]
It has also been studied for the treatment of asthma.
Pemirolast has appeared as a possible candidate for SARS-CoV-2 (COVID-19) spike protein disruption and interference. Such results were ascertained by molecular dynamics calculations executed on the Summit supercomputer. By simulating compounds with FDA or similar regulatory approval, the authors found 4 interfacial molecules that could potentially disrupt the SARS-CoV-2 interface with ACE-2 receptors, suggesting that such small molecules could mitigate SARS-CoV-2 infection. The 4 candidate interfacial molecules included pemirolast, isoniazid pyruvate, nitrofurantoin, and eriodictyol.[3]
References
- ↑ "Pemirolast ophthalmic (Alamast) Use During Pregnancy". 2 September 2020. https://www.drugs.com/pregnancy/pemirolast-ophthalmic.html.
- ↑ "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis". Cochrane Database Syst Rev 2015 (6): CD009566. 2015. doi:10.1002/14651858.CD009566.pub2. PMID 26028608.
- ↑ "Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface". Preprint: 1–28. April 2020. https://chemrxiv.org/articles/Repurposing_Therapeutics_for_the_Wuhan_Coronavirus_nCov-2019_Supercomputer-Based_Docking_to_the_Viral_S_Protein_and_Human_ACE2_Interface/11871402/4.
- "A pilot study of pemirolast in patients with seasonal allergic rhinitis". Ann Allergy 66 (2): 162–5. February 1991. PMID 1994787.
- "Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils". Int. Arch. Allergy Immunol. 103 (4): 405–9. 1994. doi:10.1159/000236662. PMID 8130655.
- "Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies". J Ocul Pharmacol Ther 18 (5): 475–88. October 2002. doi:10.1089/10807680260362759. PMID 12419098.
- "Pemirolast, a new oral nonbronchodilator drug for chronic asthma". Ann Allergy 68 (6): 488–91. June 1992. PMID 1610024.
External links
- "Pemirolast Potassium". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/pemirolast%20potassium.
 |  |
