Chemistry:Acrivastine
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth |
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| Elimination half-life | 1.5 hours |
| Excretion | Kidney |
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| Formula | C22H24N2O2 |
| Molar mass | 348.446 g·mol−1 |
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Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors.[1]
This non-sedating antihistamine is sold under the brand name Benadryl Allergy Relief in the United Kingdom by McNeil Laboratories. It should not be confused with Benadryl Once a Day which has cetirizine as the active ingredient and is also sold by McNeil in the UK, nor with the American Benadryl, which uses diphenhydramine as its active ingredient. It is available as an over-the-counter medicine in the UK, and is available with or without pseudoephedrine under the Benadryl brand.
In the U.S., acrivastine is the active ingredient in the Semprex brand. Semprex-D also contains the decongestant pseudoephedrine. Semprex-D is marketed in the U.S. by Actient Pharmaceuticals.[2]
Comparisons with other popular antihistamines
Unlike cetirizine or loratadine, for which the standard dose is one tablet per day, a single acrivastine tablet may be taken up to three times a day.[3] It is not to be taken by people over the age of 65, pregnant women, or people with compromised liver or kidney function.
References
- ↑ "Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders". Drugs 41 (6): 927–40. June 1991. doi:10.2165/00003495-199141060-00008. PMID 1715267.
- ↑ SEMPREX-D - acrivastine and pseudoephedrine hydrochloride capsule U.S. National Library of Medicine, National Institutes of Health, May 2008
- ↑ "Benadryl Allergy Relief". electronic Medicines Compendium (eMC). 2014. http://www.medicines.org.uk/EMC/pdfviewer.aspx?isAttachment=true&documentid=21852.
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