Chemistry:Dexchlorpheniramine
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Trade names | Chlor-trimeton, Polaramine |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682543 |
| Routes of administration | Oral, Intravenous |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C16H19ClN2 |
| Molar mass | 274.79 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.[1][2] It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
It came into medical use in 1959 and was patented in 1962.[3]
Pharmacology
Dexchlorpheniramine is an antihistamine, or an antagonist of the histamine H1 receptor. A study found that dexchlorpheniramine had a Ki value of 20 to 30 μM for the muscarinic acetylcholine receptors using rat brain tissue.[4]
References
- ↑ "Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance". British Journal of Clinical Pharmacology 61 (1): 79–86. January 2006. doi:10.1111/j.1365-2125.2005.02524.x. PMID 16390354.
- ↑ "[Anticholinergic syndrome due to dexchlorpheniramine as a cause of urinary retention]". Anales de Pediatria 79 (6): 400–401. December 2013. doi:10.1016/j.anpedi.2013.02.014. PMID 23680058.
- ↑ (in en) Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 547. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA547.
- ↑ "Muscarinic cholinergic binding in rat brain". Proceedings of the National Academy of Sciences of the United States of America 71 (5): 1725–1729. May 1974. doi:10.1073/pnas.71.5.1725. PMID 4151898. Bibcode: 1974PNAS...71.1725Y.
External links
 |  |
