Chemistry:Methapyrilene

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Methapyrilene is an antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC in the UK.[1] It has relatively strong sedative effects, to the extent that its primary use was as a medication for insomnia rather than for its antihistamine action. Together with scopolamine, it was the main ingredient in Sominex, Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM.[2] All of these products were reformulated in the late 1970s[3] when methapyrilene was demonstrated to cause liver cancer in rats when given chronically.[4]

See also

References

  1. ↑ "Archive.". Birmingham Post. July 1979. http://www.thefreelibrary.com/Archive.-a0119048413. 
  2. ↑ "FDA Seeks Restrictions On Sleeping Aid Drugs". Daily Press 83 (164): p. 1. 1978-06-13. https://newspapers.com/image/233886246/. 
  3. ↑ "Sleep aids back with new drug | Critics assail 'human testing'". The Minneapolis Star: pp. 1A, 6A. 1979-06-28. https://www.newspapers.com/image/191023340/. 
  4. ↑ "Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride". Science 209 (4458): 817–819. August 1980. doi:10.1126/science.7403848. PMID 7403848. Bibcode: 1980Sci...209..817L. 



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