Chemistry:Azatadine
From HandWiki
Short description: Chemical compound
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| Trade names | Optimine |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Formula | C20H22N2 |
| Molar mass | 290.410 g·mol−1 |
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Azatadine (Optimine) is a first-generation antihistamine and anticholinergic drug that was synthesized in 1963 by Schering-Plough, a former American pharmaceutical company.[1][2]
It was patented in 1967.[3] It has been succeeded by both loratadine and desloratadine.[4]:53 and marketing approvals have been widely withdrawn.[5][6][7][8]:290[9]
See also
- Azatadine/pseudoephedrine
References
- ↑ "Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis". Asian Pacific Journal of Allergy and Immunology 8 (2): 103–7. December 1990. PMID 1982614.
- ↑ "Effects of azatadine, terfenadine, and astemizole on allergen-induced nasal provocation". Annals of Allergy 64 (2 Pt 1): 129–31. February 1990. PMID 1968324.
- ↑ Villani FJ, Caldwell W, "Azatadine", US patent 3326924, issued 1967
- ↑ "Antialergic and Vasoactive Drugs for Allergic Rhinitis. Chapter 4". Allergy Frontiers:Therapy and Prevention.. 5. Springer Science & Business Media. 2010. ISBN 9784431993629.
- ↑ "Azatadine". Drugs.com. https://www.drugs.com/mtm/azatadine.html.
- ↑ Food and Drug Administration (2005). "Docket No.2005N-0058: Hospira, Inc. et al.; Withdrawal of Approval of 76 New Drug Applications and 60 Abbreviated New Drug Applications". Federal Register 70 FR 10651. https://www.federalregister.gov/articles/2005/03/04/05-4158/hospira-inc-et-al-withdrawal-of-approval-of-76-new-drug-applications-and-60-abbreviated-new-drug.
- ↑ Food and Drug Administration (2007). "Docket No. 2004P-0262: Withdrawal of Approval of 128 Suitability Petitions". Federal Register 72 FR 8184. http://www.gpo.gov/fdsys/pkg/FR-2007-02-23/html/E7-3043.htm.
- ↑ "Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals". Department of Economic and Social Affairs of the United Nations Secretariat. New York: United Nations. 2005. https://www.un.org/esa/coordination/CL12.pdf.
- ↑ "OGD Suitability Tracking Report (Sorted by Drug Name)". FDA. https://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/AbbreviatedNewDrugApplicationANDAGenerics/ucm283497.htm.
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