Chemistry:Chlorcyclizine

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Short description: Chemical compound
Chlorcyclizine
Chlorcyclizine.png
Clinical data
AHFS/Drugs.comInternational Drug Names
MedlinePlusa682619
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC18H21ClN2
Molar mass300.83 g·mol−1
3D model (JSmol)
  (verify)

Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries.[1][2][3] It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic.[1][2][3] In addition to its antihistamine effects, chlorcyclizine has some anticholinergic, antiserotonergic, and local anesthetic properties.[4][5] It has been studied as a potential treatment for various flaviviruses like hepatitis C and Zika virus.[6][7][8]

See also

References

  1. ↑ 1.0 1.1 Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. https://books.google.com/books?id=5GpcTQD_L2oC&q=Chlorcyclizine&pg=PA212. 
  2. ↑ 2.0 2.1 Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. 1996. ISBN 0-412-46630-9. https://books.google.com/books?id=DeX7jgInYFMC&q=Chlorcyclizine&pg=PA417. 
  3. ↑ 3.0 3.1 Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. 1999. ISBN 0-7514-0499-3. https://books.google.com/books?id=mqaOMOtk61IC&q=Chlorcyclizine&pg=PA72. 
  4. ↑ Dorland Staff (2008). Dorland Dictionnaire Medical Bilingue Francais-anglais / Anglais-francais: + E-book a Telecharger (French ed.). Elsevier (Educa Books). ISBN 978-2-84299-899-8. https://books.google.com/books?id=tQNqwsnkK-QC&q=chlorcyclizine%20anticholinergic&pg=PA1152. 
  5. ↑ "The effect of the antihistaminic drugs on the central action of 5-hydroxytryptophan in mice". Polish Journal of Pharmacology and Pharmacy 33 (4): 459–465. November 1981. PMID 6120505. 
  6. ↑ "Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection". Science Translational Medicine 7 (282): 282ra49. April 2015. doi:10.1126/scitranslmed.3010286. PMID 25855495. 
  7. ↑ "Benzhydrylpiperazine compounds inhibit cholesterol-dependent cellular entry of hepatitis C virus". Antiviral Research 109: 141–148. September 2014. doi:10.1016/j.antiviral.2014.06.014. PMID 25019406. 
  8. ↑ "Identification of Zika Virus NS2B-NS3 Protease Inhibitors by Structure-Based Virtual Screening and Drug Repurposing Approaches". Journal of Chemical Information and Modeling 60 (2): 731–737. February 2020. doi:10.1021/acs.jcim.9b00933. PMID 31850756. 




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