Biology:IL22RA1

Generic protein structure example

Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.

Function

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.

Further reading

• "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism". FEBS Letters 582 (20): 2985–92. September 2008. doi:10.1016/j.febslet.2008.07.046. PMID 18675809. 
• "Structure of IL-22 bound to its high-affinity IL-22R1 chain". Structure 16 (9): 1333–44. September 2008. doi:10.1016/j.str.2008.06.005. PMID 18599299. 
• "Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22". FEBS Letters 583 (7): 1072–7. April 2009. doi:10.1016/j.febslet.2009.03.006. PMID 19285080. 
• "New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain". The Journal of Biological Chemistry 284 (39): 26377–84. September 2009. doi:10.1074/jbc.M109.007955. PMID 19632985. 
• "IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22". Journal of Molecular Biology 382 (5): 1168–83. October 2008. doi:10.1016/j.jmb.2008.07.046. PMID 18675824. 
• "Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation". Journal of Molecular Cell Biology 2 (4): 223–30. August 2010. doi:10.1093/jmcb/mjq017. PMID 20671117. 
• "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes". The Journal of Biological Chemistry 276 (4): 2725–32. January 2001. doi:10.1074/jbc.M007837200. PMID 11035029. 
• "Th17-associated cytokines promote human airway smooth muscle cell proliferation". FASEB Journal 26 (12): 5152–60. December 2012. doi:10.1096/fj.12-208033. PMID 22898922. 
• "Interleukin 22 receptor 1 expression in pancreas islets". Pancreas 36 (2): 197–9. March 2008. doi:10.1097/MPA.0b013e3181594258. PMID 18376313. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.