Biology:mir-BHRF1-3 microRNA precursor family
From HandWiki
| mir-BHRF1-3 microRNA precursor family | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-BHRF1-3 | |
| Identifiers | |
| Symbol | mir-BHRF1-3 |
| Rfam | RF00367 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Viruses |
| GO | 0035195 0035068 |
| SO | 0001244 |
| PDB structures | PDBe |
The mir-BHRF1-3 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus).[1] In Epstein-Barr virus, mir-BHRF1-3 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[2] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-2.[2]
BHRF-1-3 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein–Barr virus genome.[3] BHRF-3 has been shown to be expressed in latency-III infected lymphoblasts.[4]
References
- ↑ "VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets". Database 2014: bau103. 1 January 2014. doi:10.1093/database/bau103. PMID 25380780.
- ↑ 2.0 2.1 "Identification of virus-encoded microRNAs". Science 304 (5671): 734–6. April 2004. doi:10.1126/science.1096781. PMID 15118162.
- ↑ "The members of an Epstein–Barr virus microRNA cluster cooperate to transform B lymphocytes". Journal of Virology 85 (19): 9801–10. October 2011. doi:10.1128/JVI.05100-11. PMID 21752900.
- ↑ "Epstein–Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication". Journal of Virology 81 (18): 9967–75. September 2007. doi:10.1128/JVI.02244-06. PMID 17626073.
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