Biology:mir-BHRF1-3 microRNA precursor family

From HandWiki

mir-BHRF1-3 microRNA precursor family
RF00367.jpg
Predicted secondary structure and sequence conservation of mir-BHRF1-3
Identifiers
Symbolmir-BHRF1-3
RfamRF00367
Other data
RNA typeGene; miRNA
Domain(s)Viruses
GO0035195 0035068
SO0001244
PDB structuresPDBe

The mir-BHRF1-3 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus).[1] In Epstein-Barr virus, mir-BHRF1-3 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[2] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-2.[2]

BHRF-1-3 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein–Barr virus genome.[3] BHRF-3 has been shown to be expressed in latency-III infected lymphoblasts.[4]

References

External links