Biology:mir-17 microRNA precursor family

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mir-17 microRNA precursor family
RF00051.jpg
Predicted secondary structure and sequence conservation of mir-17
Identifiers
Symbolmir-17
RfamRF00051
miRBaseMI0000071
miRBase familyMIPF0000001
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GO0035195 0035068
SO0001244
PDB structuresPDBe

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families.[1] These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA.[2][3]

The paralogous miRNA gene clusters that give rise to miR-17 family microRNAs (miR-17~92, miR-106a~363, and miR-106b~25) have been implicated in a wide variety of malignancies and are sometimes referred to as oncomirs.[4] The oncogenic potential of these non-protein encoding genes was first identified in mouse viral tumorigenesis screens.[5][6][7] In humans, the activating mutations of miR-17~92 have been identified in non-Hodgkin's lymphoma, whereas the miRNA constituents of the clusters are overexpressed in a multiple cancer types.[8][9][10] High level expression of miR-17 family members induces cell proliferation, whereas deletion of the miR-17~92 cluster, in mice, is lethal and causes lung and lymphoid cell developmental defects.[11] In addition, in the nasopharyngeal carcinoma cell line, miR-20a and miR-20b has been shown to target the 3’ UTR of vascular endothelial growth factor (VEGF) and repress the expression of VEGF, which is an important angiogenic factor.[12][13] miR-20a detection in human faeces could be a non-invasive screening marker for colorectal cancer.[14]

References

  1. ↑ "Molecular evolution of a microRNA cluster.". J Mol Biol 339 (2): 327–35. 2004. doi:10.1016/j.jmb.2004.03.065. PMID 15136036. 
  2. ↑ "Identification of novel genes coding for small expressed RNAs.". Science 294 (5543): 853–858. 2001. doi:10.1126/science.1064921. PMID 11679670. 
  3. ↑ Ambros V (2001). "microRNAs: tiny regulators with great potential.". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. 
  4. ↑ Hammond, SM. (Nov 2006). "RNAi, microRNAs, and human disease.". Cancer Chemother Pharmacol 58 (Suppl 1): s63–8. doi:10.1007/s00280-006-0318-2. PMID 17093929. 
  5. ↑ "Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.". Proc Natl Acad Sci U S A 99 (17): 11293–8. 2002. doi:10.1073/pnas.162356099. PMID 12151601. 
  6. ↑ "Activation of an oncogenic microRNA cistron by provirus integration.". Proc Natl Acad Sci U S A 103 (49): 18680–4. 2006. doi:10.1073/pnas.0609030103. PMID 17121985. 
  7. ↑ "Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia.". Cancer Res. 67 (12): 5699–707. 2007. doi:10.1158/0008-5472.CAN-06-4478. PMID 17575136. 
  8. ↑ "Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.". Cancer Res. 64 (9): 3087–95. 2004. doi:10.1158/0008-5472.CAN-03-3773. PMID 15126345. 
  9. ↑ "Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphoma.". Leuk Lymphoma 48 (2): 410–2. 2007. doi:10.1080/10428190601059738. PMID 17325905. 
  10. ↑ Mendell JT (2008). "miRiad roles for the miR-17-92 cluster in development and disease.". Cell 133 (2): 217–22. doi:10.1016/j.cell.2008.04.001. PMID 18423194. 
  11. ↑ "Targeted deletion reveals essential and overlapping functions of the miR-17~92 family of miRNA clusters.". Cell 132 (5): 875–86. 2008. doi:10.1016/j.cell.2008.02.019. PMID 18329372. 
  12. ↑ "MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia". PLOS ONE 1 (1): e116. Dec 27, 2006. doi:10.1371/journal.pone.0000116. PMID 17205120. 
  13. ↑ "The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation". PLOS ONE 3 (3): e1719. Mar 5, 2008. doi:10.1371/journal.pone.0001719. PMID 18320040. 
  14. ↑ Yau, TO; Wu, CW; Tang, CM; Chen, Y; Fang, J; Dong, Y; Liang, Q; Ng, SS et al. (12 January 2016). "MicroRNA-20a in human faeces as a non-invasive biomarker for colorectal cancer.". Oncotarget 7 (2): 1559–68. doi:10.18632/oncotarget.6403. PMID 26621842. 

Further reading

External links



  1. ↑ "The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.". Cancer Res 70 (20): 8233–46. 2010. doi:10.1158/0008-5472.CAN-10-2412. PMID 20940405. 
  2. ↑ "Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis.". Curr Genomics 11 (2): 129–35. 2010. doi:10.2174/138920210790886853. PMID 20885820. 
  3. ↑ "Suppression of p21 by c-Myc through members of miR-17 family at the post-transcriptional level.". Int J Oncol 37 (5): 1315–21. 2010. doi:10.3892/ijo_00000783. PMID 20878079. 
  4. ↑ "The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence.". Cancer Res 70 (21): 8547–57. 2010. doi:10.1158/0008-5472.CAN-10-1938. PMID 20851997. 
  5. ↑ "Review Article: let-7 and miR-17-92: Small-sized major players in lung cancer development.". Cancer Sci 102 (1): 9–17. 2010. doi:10.1111/j.1349-7006.2010.01707.x. PMID 20735434. 
  6. ↑ Jacobson, Steven, ed (2010). "MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood.". PLOS ONE 5 (8): e12132. doi:10.1371/journal.pone.0012132. PMID 20711463. 
  7. ↑ "MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis and involved in cancer cell proliferation and invasion.". Cancer Biol Ther 10 (8): 748–757. 2010. doi:10.4161/cbt.10.8.13083. PMID 20703102. 
  8. ↑ "Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts.". J Biol Chem 285 (41): 31491–501. 2010. doi:10.1074/jbc.M109.068387. PMID 20656682. 
  9. ↑ "miR-17-92 angiogenesis micromanagement.". Blood 115 (23): 4631–3. 2010. doi:10.1182/blood-2010-03-276428. PMID 20538815. 
  10. ↑ "miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1.". Breast Cancer Res Treat 126 (3): 565–575. 2010. doi:10.1007/s10549-010-0954-4. PMID 20505989. 
  11. ↑ "Control of oligodendroglial cell number by the miR-17-92 cluster". Development 137 (13): 2127–32. 2010. doi:10.1242/dev.050633. PMID 20504959. 
  12. ↑ "miR-17-92 cluster: ups and downs in cancer and aging". Biogerontology 11 (4): 501–6. 2010. doi:10.1007/s10522-010-9272-9. PMID 20437201. 
  13. ↑ "The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression". Cancer Res 70 (9): 3833–42. 2010. doi:10.1158/0008-5472.CAN-09-3268. PMID 20406979. 
  14. ↑ "De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures". Oncogene 29 (23): 3411–22. 2010. doi:10.1038/onc.2010.83. PMID 20305691. 
  15. ↑ "Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor". Cell Mol Life Sci 67 (12): 2069–76. 2010. doi:10.1007/s00018-010-0340-8. PMID 20300951. 
  16. ↑ "mir-17-92, a cluster of miRNAs in the midst of the cancer network". Int J Biochem Cell Biol 42 (8): 1348–54. 2010. doi:10.1016/j.biocel.2010.03.004. PMID 20227518. 
  17. ↑ "The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity". Development 137 (7): 1107–16. 2010. doi:10.1242/dev.046045. PMID 20215348. 
  18. ↑ "miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway". Hepatology 51 (5): 1614–23. 2010. doi:10.1002/hep.23566. PMID 20209605. 
  19. ↑ "miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy". J Transl Med 8 (1): 17. 2010. doi:10.1186/1479-5876-8-17. PMID 20167088. 
  20. ↑ "Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients". Eur J Immunol 40 (3): 888–98. 2010. doi:10.1002/eji.200940032. PMID 20148420. 
  21. ↑ "Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia". Proc Natl Acad Sci U S A 107 (8): 3710–5. 2010. doi:10.1073/pnas.0914900107. PMID 20133587. 
  22. ↑ "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging". Aging Cell 9 (2): 291–6. 2010. doi:10.1111/j.1474-9726.2010.00549.x. PMID 20089119. 
  23. ↑ "Tumorigenicity of the miR-17-92 cluster distilled". Genes Dev 24 (1): 1–4. 2010. doi:10.1101/gad.1887110. PMID 20047995. 
  24. ↑ "The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma". J Urol 183 (2): 743–51. 2010. doi:10.1016/j.juro.2009.09.086. PMID 20022054. 
  25. ↑ "miR-19 is a key oncogenic component of mir-17-92". Genes Dev 23 (24): 2839–49. 2009. doi:10.1101/gad.1861409. PMID 20008935. 
  26. ↑ "Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas". Genes Dev 23 (24): 2806–11. 2009. doi:10.1101/gad.1872909. PMID 20008931. 
  27. ↑ Poon, Art F. Y., ed (2009). "Haplotype distribution and evolutionary pattern of miR-17 and miR-124 families based on population analysis". PLOS ONE 4 (11): e7944. doi:10.1371/journal.pone.0007944. PMID 19956752. 
  28. ↑ "[The roles of miR-17-92 cluster in mammal development and tumorigenesis]". Yi Chuan 31 (11): 1094–100. 2009. doi:10.3724/SP.J.1005.2009.01094. PMID 19933089. 
  29. ↑ "MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation". Mol Biol Rep 37 (6): 2951–8. 2010. doi:10.1007/s11033-009-9861-3. PMID 19821056. 
  30. ↑ "Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis". EMBO J 28 (18): 2719–32. 2009. doi:10.1038/emboj.2009.214. PMID 19696742. 
  31. ↑ "MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression". Br J Cancer 101 (4): 707–14. 2009. doi:10.1038/sj.bjc.6605037. PMID 19672269. 
  32. ↑ "Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation". Cell Signal 21 (12): 1837–45. 2009. doi:10.1016/j.cellsig.2009.07.019. PMID 19666108. 
  33. ↑ "MicroRNA MiR-17 retards tissue growth and represses fibronectin expression". Nat Cell Biol 11 (8): 1031–8. 2009. doi:10.1038/ncb1917. PMID 19633662. 
  34. ↑ "Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancers". Oncogene 28 (38): 3371–9. 2009. doi:10.1038/onc.2009.201. PMID 19597473. 
  35. ↑ "miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution". Dev Biol 333 (2): 238–50. 2009. doi:10.1016/j.ydbio.2009.06.020. PMID 19559694. 
  36. ↑ "The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors". Cancer Res 69 (8): 3249–55. 2009. doi:10.1158/0008-5472.CAN-08-4710. PMID 19351822. 
  37. ↑ "Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma". Mod Pathol 22 (4): 547–55. 2009. doi:10.1038/modpathol.2009.10. PMID 19287466. 
  38. ↑ "The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma". Proc Natl Acad Sci U S A 106 (8): 2812–7. 2009. doi:10.1073/pnas.0809579106. PMID 19196975. 
  39. ↑ "Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia". Leuk Lymphoma 50 (1): 101–8. 2009. doi:10.1080/10428190802626632. PMID 19148830. 
  40. ↑ "miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation". Dev Biol 326 (2): 431–43. 2009. doi:10.1016/j.ydbio.2008.11.016. PMID 19073166. 
  41. ↑ "MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc". Proc Natl Acad Sci U S A 105 (50): 19678–83. 2008. doi:10.1073/pnas.0811166106. PMID 19066217. 
  42. ↑ "Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling". Cancer Res 68 (20): 8191–4. 2008. doi:10.1158/0008-5472.CAN-08-1768. PMID 18922889. 
  43. ↑ "miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression". Oncogene 28 (1): 140–5. 2009. doi:10.1038/onc.2008.372. PMID 18836483. 
  44. ↑ "The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition". Genome Biol 9 (8): R127. 2008. doi:10.1186/gb-2008-9-8-r127. PMID 18700987. 
  45. ↑ "Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype". Am J Pathol 173 (3): 856–64. 2008. doi:10.2353/ajpath.2008.080096. PMID 18688024. 
  46. ↑ "Protein tyrosine phosphatase receptor-type O (PTPRO) is co-regulated by E2F1 and miR-17-92". FEBS Lett 582 (19): 2850–6. 2008. doi:10.1016/j.febslet.2008.07.017. PMID 18644370. 
  47. ↑ "Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster". Cancer Res 68 (14): 5540–5. 2008. doi:10.1158/0008-5472.CAN-07-6460. PMID 18632605. 
  48. ↑ "Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells". Cancer Sci 99 (6): 1147–54. 2008. doi:10.1111/j.1349-7006.2008.00800.x. PMID 18429962. http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/22014/1/CanSci99_1147.pdf. 
  49. ↑ Mendell JT (2008). "miRiad roles for the miR-17-92 cluster in development and disease". Cell 133 (2): 217–22. doi:10.1016/j.cell.2008.04.001. PMID 18423194. 
  50. ↑ "Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters". Cell 132 (5): 875–86. 2008. doi:10.1016/j.cell.2008.02.019. PMID 18329372. 
  51. ↑ "Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes". Nat Immunol 9 (4): 405–14. 2008. doi:10.1038/ni1575. PMID 18327259. 
  52. ↑ "miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130". Proc Natl Acad Sci U S A 105 (8): 2889–94. 2008. doi:10.1073/pnas.0800178105. PMID 18287052. 
  53. ↑ "[DNA sequencing of miR-17-92 cluster at chromosome 13q31-q32 in mantel cell lymphoma cell lines]". Zhongguo Shi Yan Xue Ye Xue Za Zhi 15 (5): 986–8. 2007. PMID 17956675. 
  54. ↑ "Identification, amplification and characterization of miR-17-92 from canine tissue". Gene 404 (1–2): 25–30. 2007. doi:10.1016/j.gene.2007.08.015. PMID 17904311. 
  55. ↑ "Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells". Dev Biol 310 (2): 442–53. 2007. doi:10.1016/j.ydbio.2007.08.007. PMID 17765889. 
  56. ↑ "Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development". Cancer Sci 98 (9): 1482–90. 2007. doi:10.1111/j.1349-7006.2007.00531.x. PMID 17608773. 
  57. ↑ "Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92". Oncogene 26 (41): 6099–105. 2007. doi:10.1038/sj.onc.1210425. PMID 17384677. 
  58. ↑ "Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphoma". Leuk Lymphoma 48 (2): 410–2. 2007. doi:10.1080/10428190601059738. PMID 17325905. 
  59. ↑ "Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells". Blood 109 (10): 4399–405. 2007. doi:10.1182/blood-2006-09-045104. PMID 17284533. 
  60. ↑ "Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster". Cell Death Differ 14 (4): 879–82. 2007. doi:10.1038/sj.cdd.4402090. PMID 17218954. 
  61. ↑ "Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA". Mol Cell Biol 26 (21): 8191–201. 2006. doi:10.1128/MCB.00242-06. PMID 16940181. 
  62. ↑ "A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation". Cancer Res 65 (21): 9628–32. 2005. doi:10.1158/0008-5472.CAN-05-2352. PMID 16266980. 
  63. ↑ "Mapping and expression studies of the mir17-92 cluster on pig chromosome 11". Mamm Genome 16 (8): 594–8. 2005. doi:10.1007/s00335-005-0013-3. PMID 16180141. 
  64. ↑ "Novel genetic variants in microRNA genes and familial breast cancer". Int J Cancer 124 (5): 1178–82. 2009. doi:10.1002/ijc.24008. PMID 19048628. 
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