Biology:mir-938 microRNA precursor family

mir-938
Identifiers
Symbol	mir-938
Rfam	RF00964
miRBase family	MIPF0000469
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-938 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-938 and the TGF-β pathway

miR-938 has been found to directly target the SMAD3 gene, which encodes the main downstream TGF-β polypeptide SMAD3. This microRNA is overexpressed in non-functioning pituitary adenomas (NFPAs) compared with normal pituitary tissue. Downregulation of TGF-β signalling is likely to play a role in the regulation of signalling pathways in NFPA tumorigenesis, thus also implicating SMAD3 and miR-938.

See also

• MicroRNA

Further reading

• Arisawa, T.; Tahara, T.; Shiroeda, H.; Matsue, Y.; Minato, T.; Nomura, T.; Yamada, H.; Hayashi, R. et al. (2012). "Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer". Human Immunology 73 (7): 747–752. doi:10.1016/j.humimm.2012.04.011. PMID 22537748. 
• Mi, X.; He, H.; Deng, Y.; Levin, A. M.; She, J. X.; Mi, Q. S.; Zhou, L. (2011). "Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes". Diabetology & Metabolic Syndrome 3 (1): 27. doi:10.1186/1758-5996-3-27. PMID 22014115. 

External links

• Page for mir-938 microRNA precursor family at Rfam