Biology:mir-156 microRNA precursor
| miR156 microRNA precursor | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-156 | |
| Identifiers | |
| Symbol | miR156 |
| Rfam | RF00073 |
| miRBase | MI0000178 |
| miRBase family | MIPF0000008 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | 0035195 0035068 |
| SO | 0001244 |
| PDB structures | PDBe |
MicroRNA (miRNA) precursor miR156 is a family of plant non-coding RNA. This microRNA has now been predicted or experimentally confirmed in a range of plant species (MIPF0000008). Animal miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. miR156 functions in the induction of flowering by suppressing the transcripts of SQUAMOSA-PROMOTER BINDING LIKE (SPL) transcription factors gene family. It was suggested that the loading into ARGONAUTE1 and ARGONAUTE5 is required for miR156 functionality in Arabidopsis thaliana.[1] In plants the precursor sequences may be longer, and the carpel factory (caf) enzyme appears to be involved in processing. In this case the mature sequence comes from the 5' arm of the precursor, and both Arabidopsis thaliana and rice genomes contain a number of related miRNA precursors which give rise to almost identical mature sequences. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complementarity to mRNA.
This miRNA is involved in control of reproductive structures in liverworts.[2]
References
- ↑ Roussin-Léveillée, Charles; Silva-Martins, Guilherme; Moffett, Peter (2020). "ARGONAUTE5 Represses Age-Dependent Induction of Flowering through Physical and Functional Interaction with miR156 in Arabidopsis". Plant Cell Physiology 61 (5): 957–966. doi:10.1093/pcp/pcaa022. PMID 32105323.
- ↑ Tsuzuki, Masayuki; Futagami, Kazutaka; Shimamura, Masaki; Inoue, Chikako; Kunimoto, Kan; Oogami, Takashi; Tomita, Yuki; Inoue, Keisuke et al. (2019). "An Early Arising Role of the MicroRNA156/529-SPL Module in Reproductive Development Revealed by the Liverwort Marchantia polymorpha". Current Biology 29 (19): 3307–3314.e5. doi:10.1016/j.cub.2019.07.084. ISSN 0960-9822. PMID 31543452.
Further reading
- "MicroRNAs in plants". Genes & Development 16 (13): 1616–26. July 2002. doi:10.1101/gad.1004402. PMID 12101121.
- "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–6. December 2001. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- "Expression of microRNAs in cotton". Molecular Biotechnology 42 (3): 269–74. July 2009. doi:10.1007/s12033-009-9163-y. PMID 19288227.
- "Gibberellin regulates the Arabidopsis floral transition through miR156-targeted SQUAMOSA promoter binding-like transcription factors". The Plant Cell 24 (8): 3320–32. August 2012. doi:10.1105/tpc.112.101014. PMID 22942378.
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