Biology:miR-144
| miR-144 | |
|---|---|
 Conserved secondary structure of miR-144 precursor microRNA | |
| Identifiers | |
| Symbol | miR-144 |
| Alt. Symbols | MIR144 |
| Rfam | RF00682 |
| miRBase | MI0000460 |
| miRBase family | MIPF0000093 |
| NCBI Gene | 406936 |
| HGNC | 31531 |
| OMIM | 612070 |
| RefSeq | NR_029685 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 17 q11.2 |
| PDB structures | PDBe |
miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] In humans, miR-144 has been characterised as a "common miRNA signature"[2] of a number of different tumours.
GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[3]
Function
miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[4] One of the identified targets of miR-144 is insulin receptor substrate 1.[5]
Applications
miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[3]
References
- ↑ "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–6. Dec 2001. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ↑ "Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets". International Journal of Cancer 129 (7): 1624–34. Oct 2011. doi:10.1002/ijc.25818. PMID 21128228.
- ↑ 3.0 3.1 "Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death". Journal of Molecular and Cellular Cardiology 49 (5): 841–50. Nov 2010. doi:10.1016/j.yjmcc.2010.08.007. PMID 20708014.
- ↑ "The miR-144/451 locus is required for erythroid homeostasis". The Journal of Experimental Medicine 207 (7): 1351–8. Jul 2010. doi:10.1084/jem.20100458. PMID 20513743.
- ↑ "MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus". PLOS ONE 6 (8): e22839. 2011. doi:10.1371/journal.pone.0022839. PMID 21829658. Bibcode: 2011PLoSO...622839K.
- ↑ "MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field". The International Journal of Neuropsychopharmacology 13 (3): 395–404. Apr 2010. doi:10.1017/S1461145709990800. PMID 19849891.(Subscription content?)
Further reading
- "MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection". Brain Research 1383: 62–70. Apr 2011. doi:10.1016/j.brainres.2011.01.067. PMID 21276775.
External links
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