Biology:mir-395 microRNA precursor family

From HandWiki
mir-395 microRNA precursor family
RF00451.jpg
Predicted secondary structure and sequence conservation of mir-395
Identifiers
Symbolmir-395
RfamRF00451
miRBaseMI0001007
miRBase familyMIPF0000016
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GO0035195 0035068
SO0001244
PDB structuresPDBe

mir-395 is a non-coding RNA called a microRNA that was identified in both Arabidopsis thaliana and Oryza sativa computationally and was later experimentally verified. mir-395 is thought to target mRNAs coding for ATP sulphurylases.[1] The mature sequence is excised from the 3' arm of the hairpin.

miR-395 is upregulated in Arabidopsis during sulphate-limited conditions, when the mature miRNA then regulates sulphur transporters and ATP sulphurylases.[2][3]

References

  1. "Computational identification of plant microRNAs and their targets, including a stress-induced miRNA". Molecular Cell 14 (6): 787–99. June 2004. doi:10.1016/j.molcel.2004.05.027. PMID 15200956. 
  2. "MicroRNA395 mediates regulation of sulfate accumulation and allocation in Arabidopsis thaliana". The Plant Journal 62 (6): 1046–57. June 2010. doi:10.1111/j.1365-313X.2010.04216.x. PMID 20374528. 
  3. "Reciprocal regulation among miR395, APS and SULTR2;1 in Arabidopsis thaliana". Plant Signaling & Behavior 5 (10): 1257–9. October 2010. doi:10.4161/psb.5.10.12608. PMID 20935495. 

External links