Biology:mir-BHRF1-2 microRNA precursor family

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mir-BHRF1-2 microRNA precursor family
RF00366.jpg
Predicted secondary structure and sequence conservation of mir-BHRF1-2
Identifiers
Symbolmir-BHRF1-2
RfamRF00366
miRBaseMI0001065
miRBase familyMIPF0000332
Other data
RNA typeGene; miRNA
Domain(s)Viruses
GO0035195 0035068
SO0001244
PDB structuresPDBe

The mir-BHRF1-2 microRNA precursor found in human herpesvirus 4 (Epstein–Barr virus), cercopithicine herpesvirus 15 and herpesvirus papio. In Epstein-Barr virus, mir-BHRF1-2 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 3' arm of the hairpin.[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-3.[1]

BHRF-1-2 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.[2] BHRF-1-2 has been shown to be expressed in latency-III infected lymphoblasts.[3]

References

  1. 1.0 1.1 "Identification of virus-encoded microRNAs". Science 304 (5671): 734–6. April 2004. doi:10.1126/science.1096781. PMID 15118162. 
  2. "The members of an Epstein-Barr virus microRNA cluster cooperate to transform B lymphocytes". Journal of Virology 85 (19): 9801–10. October 2011. doi:10.1128/JVI.05100-11. PMID 21752900. 
  3. "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication". Journal of Virology 81 (18): 9967–75. September 2007. doi:10.1128/JVI.02244-06. PMID 17626073. 

External links