Biology:mir-145

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Short description: Non-coding RNA in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


mir-145
RF00675.png
Conserved secondary structure of mir-145
Identifiers
Symbolmir-145
RfamRF00675
miRBase familyMIPF0000079
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[1]

Targets

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin in breast cancer and endometriosis cells, resulting in a reduction of cell motility.[2][3] Larsson et al.[4] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.[5]

Role in cancer

miR-145 is hypothesised to be a tumor suppressor.[6] miR-145 has been shown to be down-regulated in breast cancer.[3] miR-145 is also involved in colon cancer [5][7][8] and acute myeloid leukemia.[9]

References

  1. ↑ "Entrez Gene: MicroRNA 145". https://www.ncbi.nlm.nih.gov/gene/406937. 
  2. ↑ Adammek, Marlene (2013). "MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors.". Fertility and Sterility 99 (5): 1346–1355.e5. doi:10.1016/j.fertnstert.2012.11.055. PMID 23312222. 
  3. ↑ 3.0 3.1 "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene 29 (50): 6569–80. Dec 2010. doi:10.1038/onc.2010.386. PMID 20818426. 
  4. ↑ "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine 1 (11): 108. 2009. doi:10.1186/gm108. PMID 19917099. 
  5. ↑ 5.0 5.1 "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene". Cancer 117 (1): 86–95. Jan 2011. doi:10.1002/cncr.25522. PMID 20737575. 
  6. ↑ "p53 represses c-Myc through induction of the tumor suppressor miR-145". Proceedings of the National Academy of Sciences of the United States of America 106 (9): 3207–12. Mar 2009. doi:10.1073/pnas.0808042106. PMID 19202062. 
  7. ↑ "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology 72 (5–6): 397–402. 2007. doi:10.1159/000113489. PMID 18196926. 
  8. ↑ Mazza, Tommaso; Mazzoccoli, Gianluigi; Fusilli, Caterina; Capocefalo, Daniele; Panza, Anna; Biagini, Tommaso; Castellana, Stefano; Gentile, Annamaria et al. (2016-05-19). "Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer". Nucleic Acids Research 44 (9): 4025–4036. doi:10.1093/nar/gkw245. ISSN 1362-4962. PMID 27067546. 
  9. ↑ "Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations". Blood 117 (2): 595–607. Jan 2011. doi:10.1182/blood-2010-03-277012. PMID 20962326. http://www.bloodjournal.org/content/117/2/595?sso-checked=true. 

Further reading

External links



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